• 14th International Symposium on Cells of the Hepatic Sinusoid 

      Smedsrød, Bård (Book; Bok, 2008-08-31)
      Abstract book of the symposium
    • Abdominal aortic aneurysms, or a relatively large diameter of non-aneurysmal aortas, increase total and cardiovascular mortality: the Tromsø study. 

      Forsdahl, Signe Helene; Solberg, Steinar; Singh, Kulbir; Jacobsen, Bjarne Koster (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      Background: In a population-based study in Tromsø, Norway, the authors assessed whether an abdominal aortic aneurysm (AAA) or the maximal infrarenal aortic diameter in a non-aneurismal aorta influence total and cardiovascular disease (CVD) mortality. Methods: A total of 6640 men and women, aged 25–84 years, were included in a 10-year mortality follow-up: 345 subjects with a diagnosed AAA and ...
    • Acculturation and self-rated health among Arctic indigenous peoples : a population-based cross-sectional study 

      Eliassen, Bent-Martin; Braaten, Tonje; Melhus, Marita; Hansen, Ketil Lenert; Broderstad, Ann Ragnhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Acculturation is for indigenous peoples related to the process of colonisation over centuries as well as the on-going social transition experienced in the Arctic today. Changing living conditions and lifestyle affect health in numerous ways in Arctic indigenous populations. Self-rated health (SRH) is a relevant variable in primary health care and in general public health assessments and monitoring. ...
    • Accumulation of stable full-length circular group i intron RNAs during heat-shock 

      Andersen, Kasper L.; Beckert, Bertrand; Masquida, Benoît; Johansen, Steinar Daae; Nielsen, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-31)
      Group I introns in nuclear ribosomal RNA of eukaryotic microorganisms are processed by splicing or circularization. The latter results in formation of full-length circular introns without ligation of the exons and has been proposed to be active in intron mobility. We applied qRT-PCR to estimate the copy number of circular intron RNA from the myxomycete Didymium iridis . In ...
    • Acquired loss of renal nuclease activity is restricted to DNase I and is an organselective feature in murine lupus nephritis 

      Seredkina, Natalya; Rekvik, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      An acquired loss of renal DNaseI has recently been shown to promote transformation of mild mesangial lupus nephritis into membrano-proliferative end-stage organ disease. In this study, we analyzed expression profiles of DNaseI in other organs of lupus-prone (NZBxNZW)F1 mice during disease progression to determine if silencing of the renal DNaseI gene is an organ specific feature or if loss of ...
    • Active and passive smoking and the risk of myocardial infarction in 24,968 men and women during 11 year of follow-up: the Tromsø Study 

      Iversen, Birgitte; Jacobsen, Bjarne Koster; Løchen, Maja-Lisa (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Active smoking is a well-established risk factor for myocardial infarction, but less is known about the impact of passive smoking, and possible sex differences in risk related to passive smoking. We investigated active and passive smoking as risk factors for myocardial infarction in an 11-year follow-up of 11,762 men and 13,206 women included in the Tromsø Study. There were a total of 769 and 453 ...
    • Acupoint Stimulation for Fibromyalgia: A Systematic Review of Randomized Controlled Trials 

      Cao, Huijuan; Li, Xun; Han, Mei; Liu, Jianping (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background. Acupoint stimulation is popular for treatment of fibromyalgia though there is lack of comprehensive evaluation of current clinical evidence for its effect and safety. Objective. To systematically review the beneficial effects and safety of acupoint stimulation for fibromyalgia. Methods. We searched six electronic databases for randomized trials on acupoint stimulation for treatment ...
    • Acupuncture Adverse Events in China: A Glimpse of Historical and Contextual Aspects 

      Birch, Stephen; Alræk, Terje; Norheim, Arne Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      The article by He and colleagues, ‘‘Adverse Events Following Acupuncture: A Systematic Review of the Chinese Literature for the Years 1956–2010’’ is an important and timely contribution. In this commentary, the article is reviewed and issues are highlighted about how to interpret and contextualize the results of their study. While their review has been well performed, certain areas have been ...
    • Administration of tetradecylthioacetic acid (TTA) stimulates myocardial fatty acid oxidation despite having a lipid-lowering effect 

      Severson, DL; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Clarke, Kieran; Hagve, Martin; Berge, Rolf; Lund, trine; Larsen, Terje; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)
    • Age- and Gender-Associated Staphylococcus aureus spa Types Found among Nasal Carriers in a General Population: the Tromsø Staph and Skin Study. 

      Sangvik, Maria; Olsen, Renate Slind; Olsen, Karina; Simonsen, Gunnar Skov; Furberg, Anne-Sofie; Sollid, johanna u ericson (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Staphylococcus aureus nasal carriers risk autoinfection; however, knowledge about the factors that make specific strains successful colonizers is limited. This study was undertaken to identify the most successful S. aureus clones in nasal carriers and compare their distribution among host groups. The population structure of S. aureus isolates from healthy adults was investigated by spa typing 1,981 ...
    • Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy 

      Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Protein aggregation is a continuous process in our cells. Some proteins aggregate in a regulated manner required for different vital functional processes in the cells whereas other protein aggregates result from misfolding caused by various stressors. The decision to form an aggregate is largely made by chaperones and chaperone-assisted proteins. Proteins that are damaged beyond repair are degraded ...
    • Agnoprotein of polyomavirus BK interacts With proliferating cell nuclear antigen and inhibits DNA replication 

      Gerits, Nancy; Johannessen, Mona; Tümmler, Conny; Walquist, Mari; Kostenko, Sergiy; Snapkov, Igor; van Loon, Barbara; Ferrari, Elena; Hübscher, Ulrich; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-01)
      Background: The human polyomavirus BK expresses a 66 amino-acid peptide referred to as agnoprotein. Though mutants lacking agnoprotein are severely reduced in producing infectious virions, the exact function of this peptide remains incompletely understood. To elucidate the function of agnoprotein, we searched for novel cellular interaction partners. <p>Methods: Yeast-two hybrid assay was performed ...
    • Agreement between diagnoses of childhood lymphoma assigned in Uganda and by an international reference laboratory 

      Orem, J; Sandin, S; Weibull, CE; Odida, M; Wabinga, H; Mbidde, EK; Wabwire-Mangen, F; Meijer, CJ; Middeldorp, JM; Weiderpass, Elisabete (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Correct diagnosis is key to appropriate treatment of cancer in children. However, diagnostic challenges are common in low-income and middle-income countries. The objective of the present study was to assess the agreement between a clinical diagnosis of childhood non-Hodgkin lymphoma (NHL) assigned in Uganda, a pathological diagnosis assigned in Uganda, and a pathological diagnosis assigned in The ...
    • Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis 

      Becker-Merok, Andrea; Kalaaji, Manar; Haugbro, Kaia; Nikolaisen, Cathrin; Nilsen, Kirsten; Rekvig, Ole Petter; Nossent, Johannes C (Journal article; Tidsskriftartikkel; Peer reviewed, 2006-10-24)
      This study investigated the overall clinical impact of anti-α- actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody (ANA)- positive individuals. The relation of anti-α-actinin antibodies with lupus nephritis and anti-double-stranded DNA (anti-dsDNA) antibodies represented a particular focus for the study. Using a cross-sectional ...
    • Altered pharmacological effects of adrenergic agonists during hypothermia 

      Dietrichs, Erik Sveberg; Sager, Georg; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-05)
      Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiac dysfunction, calling for immediate pharmacologic intervention. Studies show that although cardiac pharmacologic support is applied when rewarming these patients, a lack of updated treatment recommendations exist. Mainly due to lack of clinical and experimental data, neither of the international guidelines ...
    • Aneuploidy prediction and tumor classification with heterogeneous hidden conditional random fields 

      Barutcuoglu, Z; Airoldi, EM; Dumeaux, vanessa; Schapire, RE; Troyanskaya, Olga (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)
      The heterogeneity of cancer cannot always be recognized by tumor morphology, but may be reflected by the underlying genetic aberrations. Array comparative genome hybridization (array-CGH) methods provide high-throughput data on genetic copy numbers, but determining the clinically relevant copy number changes remains a challenge. Conventional classification methods for linking recurrent alterations ...
    • Anti-dsDNA Antibodies Promote Initiation, and Acquired Loss of Renal Dnase1 Promotes Progression of Lupus Nephritis in Autoimmune (NZBxNZW)F1 mice 

      Fenton, Kristin Andreassen; Fismen, Silje; Hedberg, Annica; Seredkina, Natalya; Fenton, Christopher Graham; Mortensen, Elin; Rekvik, Ole Petter (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)
    • Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: A laboratory study using an in vitro model 

      Eksteen, Mariana; Heide, Gøril; Tiller, Heidi; Zhou, Yan; Nedberg, Nora Hersoug; Martinez-Zubiaurre, Inigo; Husebekk, Anne; Skogen, Bjørn Ragnar; Stuge, Tor Brynjar; Kjær, Mette (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-21)
      Background: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are accountable for the majority of FNAIT cases. We have previously shown that high levels of maternal anti-HPA-1a antibodies are associated with clinically significant reduced birth ...
    • Anti-human platelet antigen-1α immunoglobulin G preparation intended to prevent fetal and neonatal alloimmune thrombocytopenia 

      Weng, Ying-Jan; Husebekk, Anne; Skogen, Bjørn Ragnar; Killie, Mette Kjær; Lin, Liang-Tzung; Burnouf, Thierry (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-14)
      Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a severe disease that is caused by maternal alloantibodies generated during pregnancy or at delivery as a result of incompatibility between maternal and fetal human platelet antigens (HPAs) inherited from the father. Antibody-mediated immune suppression using anti-HPA-1a immunoglobulins is thought to be able to prevent FNAIT caused by ...
    • Antibiotics to outpatients in Norway—Assessing effect of latitude and municipality population size using quantile regression in a cross-sectional study. 

      Haugen, Pål; Simonsen, Gunnar Skov; Primicerio, Raul; Furberg, Anne-Sofie; Småbrekke, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-29)
      High antibiotic consumption rates are associated to high prevalence of antimicrobial resistance. Geographical differences in dispensing rates of antibiotics are frequently analysed using statistical methods addressing the central tendency of the data. Yet, examining extreme quantiles may be of equal or greater interest if the problem relates to the extremes of consumption rates, as is the case for ...