Blar i tittel Artikler, rapporter og annet (medisinsk biologi)

Viser treff 650-669 av 1054

    • NADPH oxidase 2 mediates myocardial oxygen wasting in obesity 

      Hafstad, Anne Dragøy; Hansen, Synne Simonsen; Lund, Jim; Santos, Celio X.C.; Boardman, Neoma Tove; Shah, Ajay M.; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-19)
      Obesity and diabetes are independent risk factors for cardiovascular diseases, and they are associated with the development of a specific cardiomyopathy with elevated myocardial oxygen consumption (MVO<sub>2</sub>) and impaired cardiac efficiency. Although the pathophysiology of this cardiomyopathy is multifactorial and complex, reactive oxygen species (ROS) may play an important role. One of the ...

    • Nationwide, population-based observational study of the molecular epidemiology and temporal trend of carbapenemase-producing Enterobacterales in Norway, 2015 to 2021 

      Ljungquist, Oskar; Haldorsen, Bjørg; Pöntinen, Anna Kaarina; Janice, Jessin; Josefsen, Ellen Haldis; Elstrøm, Petter; Kacelnik, Oliver; Sundsfjord, Arnfinn; Samuelsen, Ørjan; Handal, Nina; Ranheim, Trond Egil; Hansen, Bent-Are; Mjøen, Andreas Fossum; Lindemann, Paul Christoffer; Nilsen, Einar; Zaragkoulias, Kyriakos; Larsen, Hege Elisabeth; Bjørnholt, Jørgen; Gammelsrud, Karianne Wiger; Jakovljev, Aleksandra; Löhr, Iren Høyland; Bredberg, Anders; Marvik, Åshild; Minge, Christina; Tofteland, Ståle; Papp, Kristina; Onken, Annette; Weme, Einar Tollaksen; Guennigsman, Brian Albert (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)
      National and regional carbapenemaseproducing Enterobacterales (CPE) surveillance is essential to understand the burden of antimicrobial resistance, elucidate outbreaks, and develop infection-control or antimicrobial-treatment recommendations. Aim: This study aimed to describe CPE and their epidemiology in Norway from 2015 to 2021. Methods: A nationwide, population-based observational study of ...

    • NBR1: The archetypal selective autophagy receptor 

      Rasmussen, Nikoline Lander; Kournoutis, Athanasios; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-18)
      NBR1 was discovered as an autophagy receptor not long after the first described vertebrate autophagy receptor p62/SQSTM1. Since then, p62 has currently been mentioned in >10,000 papers on PubMed, while NBR1 is mentioned in <350 papers. Nonetheless, evolutionary analysis reveals that NBR1, and likely also selective autophagy, was present already in the last eukaryotic common ancestor (LECA), while ...

    • The need for and barriers to professional help - a qualitative study of the bereaved in Sami areas 

      Dyregrov, Kari; Berntsen, Gro; Silviken, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Nephronectin as a matrix effector in cancer 

      Norvoll Magnussen, Synnøve; Toraskar, Jimita Prashant; Hadler-Olsen, Elin Synnøve; Steigedal, Tonje S.; Svineng, Gunbjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-25)
      The extracellular matrix protein nephronectin plays an important regulatory role during embryonic development, controlling renal organogenesis through integrin α8β1 association. Nephronectin has three main domains: five N-terminal epidermal growth factor-like domains, a linker region harbouring two integrin-binding motifs (RGD and LFEIFEIER), and a C-terminal MAM domain. In this review, we look into ...

    • Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs 

      Steigedal, Tonje S.; Toraskar, Jimita; Redvers, Richard P.; Valla, Marit; Magnussen, Synnøve; Bofin, Anna M.; Opdahl, Signe; Lundgren, Steinar; Eckhardt, Bedrich L.; Lamar, John M.; Doherty, Judy; Hynes, Richard O.; Anderson, Robin L.; Svineng, Gunbjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-11)
      Most cancer patients with solid tumors who succumb to their illness die of metastatic disease. While early detection and improved treatment have led to reduced mortality, even for those with metastatic cancer, some patients still respond poorly to treatment. Understanding the mechanisms of metastasis is important to improve prognostication, to stratify patients for treatment, and to identify new ...

    • Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif 

      Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-30)
      Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in an integrin‐dependent manner. Here, we used reverse‐phase protein array (RPPA) to analyze NPNT‐triggered intracellular signaling in the 66cl4 mouse breast cancer cell line. The results ...

    • Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains 

      Norvoll Magnussen, Synnøve; Toraskar, Jimita Prashant; Wilhelm, Imola; Hasko, Janos; Figenschau, Stine; Molnar, Judit; Seppola, Marit; Steigen, Sonja Eriksson; Steigedal, Tonje S.; Hadler-Olsen, Elin Synnøve; Krizbai, Istvan; Svineng, Gunbjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-22)
      This study demonstrates a role for the extracellular matrix protein nephronectin (NPNT) in promoting experimental breast cancer brain metastasis, possibly through enhanced binding to- and migration through brain endothelial cells. With the introduction of more targeted breast cancer treatments, a prolonged survival has resulted during the last decade. Consequently, an increased number of patients ...

    • Nestin-expressing progenitor cells: function, identity and therapeutic implications 

      Bernal Mera, Aurora; Arranz, Lorena (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-03-14)
      The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cells with progenitor and/or regulatory functions in a number of additional tissues, remarkably bone marrow. This review presents the current knowledge on the role ...

    • Neuroinflammatory processes are augmented in mice overexpressing human heat-shock protein B1 following ethanol-induced brain injury 

      Dukay, Brigitta; Walter, Fruzsina; Vigh, Judit; Barabasi, Beata; Hajdu, Petra; Balassa, Tamas; Migh, Ede; Kincses, Andras; Hoyk, Zsofia; Szogi, Titanilla; Borbely, Emoke; Csoboz, Balint; Horvath, Peter; Fulop, Livia; Penke, Botond; Vigh, Laszlo; Deli, Maria; Santha, Mikos; Toth, Melinda (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-10)
      Background - Heat-shock protein B1 (HSPB1) is among the most well-known and versatile member of the evolutionarily conserved family of small heat-shock proteins. It has been implicated to serve a neuroprotective role against various neurological disorders via its modulatory activity on inflammation, yet its exact role in neuroinflammation is poorly understood. In order to shed light on the exact ...

    • NIMA-related kinase 9–mediated phosphorylation of the microtubule-associated LC3B protein at Thr-50 suppresses selective autophagy of p62/sequestosome 1 

      Shrestha, Birendra Kumar; Rasmussen, Mads Skytte; Abudu, Yakubu Princely; Bruun, Jack-Ansgar; Larsen, Kenneth Bowitz; Alemu, Endalkachew Ashenafi; Sjøttem, Eva; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-19)
      Human ATG8 family proteins (ATG8s) are active in all steps of the macroautophagy pathway, and their lipidation is essential for autophagosome formation. Lipidated ATG8s anchored to the outer surface of the phagophore serve as scaffolds for binding of other core autophagy proteins and various effector proteins involved in trafficking or fusion events, whereas those at the inner surface are needed for ...

    • NIPSNAP1 and NIPSNAP2 Act as “Eat Me” Signals for Mitophagy 

      Abudu, Yakubu Princely; Pankiv, Serhiy; Mathai, Benan John; Lystad, Alf Håkon; Bindesbøll, Christian; Brenne, Hanne Britt; Ng, Matthew Yoke Wui; Thiede, Bernd; Yamamoto, Ai; Nthiga, Thaddaeus Mutugi; Lamark, Trond; Esguerra, Camila Vicencio; Johansen, Terje; Simonsen, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-11)
      The clearance of damaged or dysfunctional mitochondria by selective autophagy (mitophagy) is important for cellular homeostasis and prevention of disease. Our understanding of the mitochondrial signals that trigger their recognition and targeting by mitophagy is limited. Here, we show that the mitochondrial matrix proteins 4-Nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog ...

    • No Effect of Calanus Oil on Maximal Oxygen Uptake in Healthy Participants: A Randomized Controlled Study 

      Tauschek, Lucas Christian; Røsbjørgen, Ragnhild; Dalen, Håvard; Larsen, Terje; Karlsen, Trine (Journal article; Tidsskriftartikkel, 2022-08-23)
      We aimed to investigate the long-term effect of daily Calanus oil supplementation on maximal oxygen uptake (VO<sub>2</sub>max) in healthy 30- to 50-year-old participants. The study was motivated by preclinical studies reporting increased VO<sub>2</sub>max and metabolic health with omega-3 rich Calanus oil. In a double-blinded study, 71 participants were randomized to receive 2 g/day of Calanus or ...

    • NORM/NORM-VET 2016 - Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway 

      Simonsen, Gunnar Skov; Urdahl, Anne Margrete (Research report; Forskningsrapport, 2017)
      Antimicrobial resistance is an emerging problem worldwide. It reduces the effectiveness of antimicrobial treatment of infectious diseases in humans and animals thereby leading to increased morbidity and mortality, as well as higher costs. It is well established that there is a strong association between the usage of antimicrobial agents and the occurrence of resistance, The selective pressure exerted ...

    • NORM/NORM-VET 2020 

      Simonsen, Gunnar Skov; Blix, Hege Salvesen; Grave, Kari; Urdahl, Anne Margrete (Research report; Forskningsrapport, 2021)

    • NORM/NORM-VET 2021: Usage of Antimicrobial Agents and Occurrence of Antimicrobial Resistance in Norway 

      Akselsen, Per Espen; Andersen, Cecilie Torp; Caugant, Dominique Andree Yvette; Dansie, Live Storehagen; Elstrøm, Petter (Research report; Forskningsrapport, 2022)
      Veterinærinstituttet overvåker forekomst av antibiotikaresistens i mikrober fra fôr, dyr og næringsmidler på oppdrag fra Mattilsynet. Dette gjøres i regi av NORM-VET, som er forkortelse for «Norsk overvåkingsprogram for antibiotikaresistens i mikrober fra fôr, dyr og næringsmidler». Data fra NORM-VET publiseres i den årlige NORM/NORM-VET rapporten som presenterer data om forekomst av antibiotikaresistens ...

    • Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation 

      Kostovski, Emil; Frigato, E; Savikj, Mladen; Dahm, Anders Erik A; Sandset, Per Morten; Mowinckel, Marie-Christine; Skretting, Grethe; Østerud, Bjarne; Bertolucci, C; Iversen, Per Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-09)
      <i>Study design</i>: Crossover double blind, randomized placebo-controlled trial.<p> <p><i>Objectives</i>: Circadian oscillators are located both in the brain and in peripheral organs. Melatonin, the main brain-derived hormone governing circadian variations, is highly associated with daylight patterns. However, in subjects with tetraplegia the melatonin levels are blunted. Here we studied peripheral ...

    • Norwegian General Practitioners’ Perspectives on Implementation of a Guided Web-Based Cognitive Behavioral Therapy for Depression: A Qualitative Study 

      Wilhelmsen, Maja; Høifødt, Ragnhild Sørensen; Kolstrup, nils; Waterloo, Knut; Eisemann, Martin; Chenhall, Richard; Risør, Mette Bech (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Novel chemical-physical autopsy investigation in sudden infant death and sudden intrauterine unexplained death syndromes 

      Gatti, Antonietta M; Ristic, Marko; Stanzani, Stefano; Lavezzi, Anna M (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-08)
      Aim: Verify the presence of inorganic nanoparticle entities in brain tissue samples from sudden infant death syndrome (SIDS)/sudden intrauterine unexplained death syndrome (SIUDS) cases. The presence of inorganic debris could be a cofactor that compromises proper brain tissue functionality. Materials & methods: A novel autopsy approach that consists of neuropathological analysis procedures ...

    • Novel genomic islands and a new vanDsubtype in the first sporadic VanD-type vancomycin resistant enterococci in Norway 

      AL-Rubaye, Mushtaq Talib Shawi; Janice, Jessin; Bjørnholt, Jørgen Vildershøj; Jakovljev, Aleksandra; Hultström, Maria Elisabeth; Sundsfjord, Arnfinn; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-23)
      Background - Vancomycin-resistant enterococci (VRE) represent several types of transferable vancomycin resistance gene clusters. The vanD type, associated with moderate to high level vancomycin resistance, has only sporadically been described in clinical isolates. The aim of this study was to perform a genetic characterization of the first VanD-type VRE strains detected in Norway.<p> <p>Methods ...