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Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif

Permanent lenke
https://hdl.handle.net/10037/14423
DOI
https://doi.org/10.1002/2211-5463.12544
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article.pdf (1012.Kb)
Publisher's version (PDF)
Dato
2018-10-30
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Toraskar, Jimita Prashant; Magnussen, Synnøve; Chawla, Konika; Svineng, Gunbjørg; Steigedal, Tonje S.
Sammendrag
Nephronectin (NPNT) is an extracellular matrix (ECM) protein involved in kidney development. We recently reported intracellular NPNT as a potential prognostic marker in breast cancer and that NPNT promotes metastasis in an integrin‐dependent manner. Here, we used reverse‐phase protein array (RPPA) to analyze NPNT‐triggered intracellular signaling in the 66cl4 mouse breast cancer cell line. The results showed that the integrin‐binding enhancer motif is important for the cellular effects upon NPNT interaction with its receptors, including phosphorylation of p38 mitogen‐activated protein kinase (MAPK). Furthermore, analysis using prediction tools suggests involvement of NPNT in promoting cell viability. In conclusion, our results indicate that NPNT, via its integrin‐binding motifs, promotes cell viability through phosphorylation of p38 MAPK.
Beskrivelse
Source at https://doi.org/10.1002/2211-5463.12544.
Forlag
Elsevier
Sitering
Toraskar, J., Magnussen, S.N., Chawla, K., Svineng, G. & Steigedal, T.S. (2018). Nephronectin mediates p38 MAPK‐induced cell viability via its integrin binding enhancer motif. FEBS Open Bio. https://doi.org/10.1002/2211-5463.12544
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  • Artikler, rapporter og annet (medisinsk biologi) [1105]

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