Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis
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https://hdl.handle.net/10037/1105DOI
doi:10.1186/ar2070Date
2006-10-24Type
Journal articleTidsskriftartikkel
Peer reviewed
Author
Becker-Merok, Andrea; Kalaaji, Manar; Haugbro, Kaia; Nikolaisen, Cathrin; Nilsen, Kirsten; Rekvig, Ole Petter; Nossent, Johannes CAbstract
This study investigated the overall clinical impact of anti-α-
actinin antibodies in patients with pre-selected autoimmune
diseases and in a random group of anti-nuclear antibody (ANA)-
positive individuals. The relation of anti-α-actinin antibodies with
lupus nephritis and anti-double-stranded DNA (anti-dsDNA)
antibodies represented a particular focus for the study. Using a
cross-sectional design, the presence of antibodies to α-actinin
was studied in selected groups, classified according to the
relevant American College of Rheumatology classification
criteria for systemic lupus erythematosus (SLE) (n = 99),
rheumatoid arthritis (RA) (n = 68), Wegener's granulomatosis
(WG) (n = 85), and fibromyalgia (FM) (n = 29), and in a random
group of ANA-positive individuals (n = 142). Renal disease was
defined as (increased) proteinuria with haematuria or presence
of cellular casts. Sera from SLE, RA, and Sjøgren's syndrome
(SS) patients had significantly higher levels of anti-α-actinin
antibodies than the other patient groups. Using the geometric
mean (± 2 standard deviations) in FM patients as the upper
cutoff, 20% of SLE patients, 12% of RA patients, 4% of SS
patients, and none of the WG patients were positive for anti-α-
actinin antibodies. Within the SLE cohort, anti-α-actinin
antibody levels were higher in patients with renal flares (p =
0.02) and correlated independently with anti-dsDNA antibody
levels by enzyme-linked immunosorbent assay (p < 0.007) but
not with other disease features. In the random ANA group, 14
individuals had anti-α-actinin antibodies. Of these, 36% had
SLE, while 64% suffered from other, mostly autoimmune,
disorders. Antibodies binding to α-actinin were detected in 20%
of SLE patients but were not specific for SLE. They correlate
with anti-dsDNA antibody levels, implying in vitro crossreactivity
of anti-dsDNA antibodies, which may explain the
observed association with renal disease in SLE.
Publisher
BioMed CentralCitation
Arthritis research & therapy 8(2006), R162 pp 8Metadata
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