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dc.contributor.authorBecker-Merok, Andrea
dc.contributor.authorKalaaji, Manar
dc.contributor.authorHaugbro, Kaia
dc.contributor.authorNikolaisen, Cathrin
dc.contributor.authorNilsen, Kirsten
dc.contributor.authorRekvig, Ole Petter
dc.contributor.authorNossent, Johannes C
dc.date.accessioned2007-07-20T07:41:51Z
dc.date.available2007-07-20T07:41:51Z
dc.date.issued2006-10-24
dc.description.abstractThis study investigated the overall clinical impact of anti-α- actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody (ANA)- positive individuals. The relation of anti-α-actinin antibodies with lupus nephritis and anti-double-stranded DNA (anti-dsDNA) antibodies represented a particular focus for the study. Using a cross-sectional design, the presence of antibodies to α-actinin was studied in selected groups, classified according to the relevant American College of Rheumatology classification criteria for systemic lupus erythematosus (SLE) (n = 99), rheumatoid arthritis (RA) (n = 68), Wegener's granulomatosis (WG) (n = 85), and fibromyalgia (FM) (n = 29), and in a random group of ANA-positive individuals (n = 142). Renal disease was defined as (increased) proteinuria with haematuria or presence of cellular casts. Sera from SLE, RA, and Sjøgren's syndrome (SS) patients had significantly higher levels of anti-α-actinin antibodies than the other patient groups. Using the geometric mean (± 2 standard deviations) in FM patients as the upper cutoff, 20% of SLE patients, 12% of RA patients, 4% of SS patients, and none of the WG patients were positive for anti-α- actinin antibodies. Within the SLE cohort, anti-α-actinin antibody levels were higher in patients with renal flares (p = 0.02) and correlated independently with anti-dsDNA antibody levels by enzyme-linked immunosorbent assay (p < 0.007) but not with other disease features. In the random ANA group, 14 individuals had anti-α-actinin antibodies. Of these, 36% had SLE, while 64% suffered from other, mostly autoimmune, disorders. Antibodies binding to α-actinin were detected in 20% of SLE patients but were not specific for SLE. They correlate with anti-dsDNA antibody levels, implying in vitro crossreactivity of anti-dsDNA antibodies, which may explain the observed association with renal disease in SLE.en
dc.format.extent273701 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationArthritis research & therapy 8(2006), R162 pp 8en
dc.identifier.issn1478-6362
dc.identifier.otherdoi:10.1186/ar2070
dc.identifier.urihttp://hdl.handle.net/10037/1105
dc.identifier.urnURN:NBN:no-uit_munin_926
dc.language.isoengen
dc.publisherBioMed Centralen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Rheumatology: 759en
dc.subjectreumatologien
dc.titleAlpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritisen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer reviewed


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