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dc.contributor.authorHunt, Nicholas J
dc.contributor.authorMcCourt, Peter Anthony
dc.contributor.authorLe Couteur, David George
dc.contributor.authorCogger, Victoria C
dc.date.accessioned2019-08-22T11:43:42Z
dc.date.available2019-08-22T11:43:42Z
dc.date.issued2018-09-21
dc.description.abstractAge-related changes in liver function have a significant impact on systemic aging and susceptibility to age-related diseases. Nutrient sensing pathways have emerged as important targets for the development of drugs that delay aging and the onset age-related diseases. This supports a central role for the hepatic regulation of metabolism in the association between nutrition and aging. Recently, a role for liver sinusoidal endothelial cells (LSECs) in the relationship between aging and metabolism has also been proposed. Age-related loss of fenestrations within LSECs impairs the transfer of substrates (such as lipoproteins and insulin) between sinusoidal blood and hepatocytes, resulting in post-prandial hyperlipidemia and insulin resistance. Targeted drug delivery methods such as nanoparticles and quantum dots will facilitate the direct delivery of drugs that regulate fenestrations in LSECs, providing an innovative approach to ameliorating age-related diseases and increasing healthspan.en_US
dc.description.sponsorshipNational Health and Medical Research Council of Australia Ageing and Alzheimer’s Research Foundation (a division of the Medical Foundation of the University of Sydney)en_US
dc.descriptionSubmitted manuscript version. Published version in <i>Advanced Drug Delivery Reviews, 135</i>, 39-49, is available at <a href=https://doi.org/10.1016/j.addr.2018.09.006>https://doi.org/10.1016/j.addr.2018.09.006. </a>en_US
dc.identifier.citationHunt, N.J., McCourt, P.A.G., Le Couteur, D.G. & Cogger, V.C. (2018). Novel targets for delaying aging: The importance of the liver and advances in drug delivery. <i>Advanced Drug Delivery Reviews, 135</i>, 39-49. https://doi.org/10.1016/j.addr.2018.09.006en_US
dc.identifier.cristinIDFRIDAID 1627913
dc.identifier.doi10.1016/j.addr.2018.09.006
dc.identifier.issn0169-409X
dc.identifier.issn1872-8294
dc.identifier.urihttps://hdl.handle.net/10037/15993
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalAdvanced Drug Delivery Reviews
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.subjectNutrient sensing pathwaysen_US
dc.subjectHepaticen_US
dc.subjectNanoparticleen_US
dc.subjectReviewen_US
dc.subjectNovelen_US
dc.subjectNicotinamideen_US
dc.subjectQuantum doten_US
dc.subjectLSECen_US
dc.subjectMetabolismen_US
dc.titleNovel targets for delaying aging: The importance of the liver and advances in drug deliveryen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePreprinten_US
dc.typeManuskripten_US


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