Intestinal drug absorption following oral administration can be influenced by regional conditions (absorbing surface area, bacterial flora, motility, pH, mucus thickness) and food intake, all of which affect drug solubility and permeability. Therefore, it is crucial to assess the impact of these conditions on the drugability of drugs and formulations. In this study, the ability of the liposome-based ...

As one of the most physically demanding sports in the Olympic Games, crosscountry skiing poses considerable challenges with respect to both force generation and endurance during the combined upper- and lower-body effort of varying intensity and duration. The isoforms of myosin in skeletal muscle have long been considered not only to define the contractile properties, but also to determine metabolic ...

<i>Background</i>: Family member’s experience and satisfaction of health care in the acute care and in-patient rehabilitation are important indicators of the quality of health care services provided to patients with severe traumatic brain injury (TBI). The objective was to assess family members’ experience of the health care provided in-hospital to patients with severe TBI, to relate experiences ...

Platelet transfusion can elicit alloimmune responses leading to alloantibody formation against donor-specific polymorphic residues, ultimately resulting in platelet transfusion refractoriness. Universal leukoreduction significantly reduced the frequency of alloimmunization after platelet transfusion, thereby showing the importance of white blood cells (WBCs) in inducing this alloresponse. It is, ...

Climate change is one of many ongoing human-induced environmental changes, but few studies consider interactive effects between multiple anthropogenic disturbances. In coastal sub-arctic heathland, we quantified the impact of a factorial design simulating extreme winter warming (WW) events (7 days at 6–7∘C) combined with episodic summer nitrogen (+N) depositions (5 kg N ha-1) on plant winter physiology, ...

<p><i>Background - </i>Although choline metabolism has been associated with atherosclerotic heart disease, less research attention has been paid to the associations of choline and its oxidative metabolite betaine with cardiac arrhythmias. <p><i>Methods and Results - </i>We evaluated associations of plasma concentrations and dietary intakes of choline and betaine with long-term atrial fibrillation ...

The implementation of novel cancer immunotherapies in the form of immune checkpoint blockers represents a major advancement in the treatment of cancer, and has renewed enthusiasm for identifying new ways to induce antitumor immune responses in patients. Despite the proven efficacy of neutralizing antibodies that target immune checkpoints in some refractory cancers, many patients do not experience ...

<i>Objectives</i>: The objectives of this study were to assess the interexaminer agreement between one “reference” (gold standard) and each of two examiners, using the DC/TMD examination method, Axis I and to evaluate whether a recalibration changed reliability values. <p> <p><i>Methods</i>: Participants (4 healthy and 12 TMD patients) in 2013 underwent a clinical examination according to ...

Formålet med artikkelen er å få innsikt i studenters oppfatninger av god og dårlig praksisveiledning i barnehagelærerutdanningen, noe som er avgjørende for å utvikle praksisveiledningens kvalitet. Studentperspektivet på praksisveiledningens kvalitet er lite fremtredende i nordisk forskning på barnehagelærerutdanning. Studien er basert på fire fokusgrupper, der studenter fra 1.-3. studieår i ...

This study investigates the impact that discourse topic has on (i) word order (global marking) and (ii) referring expression (local marking), in ditransitive structures in Croatian preschoolers and adult controls. According to general pragmatic principles, the discourse topic argument is expected to be placed before the rest of the sentence, thus complying with the (discourse) topic-comment order ...