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    • Tuberkulosekontroll i Peru. Resultatene fra et WHO basert program innført i 1990 

      Molina, Freddy (Master thesis; Mastergradsoppgave, 2002-10)

    • Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report 

      Bjerkli, Inger-Heidi; Laurvik, Helene; Nginamau, Elisabeth Sivy; Søland, Tine Merete; Costea, Daniela Elena; Hov, Håkon; Uhlin-Hansen, Lars; Hadler-Olsen, Elin Synnøve; Steigen, Sonja Eriksson (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-25)
      <i>Background</i> - The majority of oral cavity cancers arise in the oral tongue. The aim of this study was to evaluate the prognostic value of tumor budding in oral tongue squamous cell carcinoma, both as a separate variable and in combination with depth of invasion. We also assessed the prognostic impact of the 8th edition of the American Joint Committee on Cancer’s TNM classification (TNM8), where ...

    • Tumor hypoxia and hypoxic markers in non-small cell lung cancer 

      Eilertsen, Marte (Doctoral thesis; Doktorgradsavhandling, 2014-03-14)

    • Tumor lysis with LTX-401 creates anticancer immunity 

      Xie, Wei; Mondragon, Laura; Mauseth, Brynjar; Wang, Yan; Pol, Jonathan; Levesque, Sarah; Zhou, Heng; Yamazaki, Takahiro; Eksteen, Jacobus Johannes; Zitvogel, Laurence; Sveinbjørnsson, Baldur; Rekdal, Øystein; Kepp, Oliver; Kroemer, Guido (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-04-13)
      Local immunotherapies such as the intratumoral injection of oncolytic compounds aim at reinstating and enhancing systemic anticancer immune responses. LTX-315 is a first-in-class, clinically evaluated oncolytic peptide-based local immunotherapy that meets these criteria. Here, we show that LTX-401, yet another oncolytic compound designed for local immunotherapy, depicts a similar safety profile and ...

    • Tumor Necrosis Factor and the Tenacious α. 

      Grimstad, Øystein (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05)

    • Tumor necrosis factor inhibitors are associated with reduced complement activation in spondylarthropathies: An observational study 

      Hokstad, Ingrid; Deyab, Gia; Fagerland, Morten; Lyberg, Torstein; Hjeltnes, Gunnbjørg; Førre, Øystein Thorleiv; Agewall, Stefan; Mollnes, Tom Eirik; Hollan, Ivana (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-23)
      <i>Background</i> - The complement system is involved in pathogenesis of cardiovascular disease, and might play a role in accelerated atherogenesis in spondylarthropathies (SpA). Hence, we examined complement activation in SpA, and its relationship to antirheumatic treatment, inflammatory and cardiovascular markers. <p> <p><i>Methods</i> - From PSARA, a prospective observational study, we examined ...

    • Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas 

      Dancsok, Amanda R.; Gao, Dongxia; Lee, Anna F.; Steigen, Sonja Eriksson; Blay, Jean-Yves; Thomas, David M.; Maki, Robert G.; Nielsen, Torsten O.; Demicco, Elizabeth G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-12)
      Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages. To enhance our understanding of the sarcoma immune landscape, we quantified and characterized tumor-associated macrophage infiltration and expression of the targetable ...

    • Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis? 

      Karinen, Sini; Juurikka, Krista; Hujanen, Roosa; Whabi, Wafa; Hadler-Olsen, Elin Synnøve; Svineng, Gunbjørg; Eklund, Kari K.; Salo, Tuula; Åström, Pirjo; Salem, Abdelhakim (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-05)
      Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date. The lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1), a specific lymphatic marker, is associated with poor survival in OSCC patients. In this study, we present a potential ...

    • Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes 

      Magnussen, Synnøve; Hadler-Olsen, Elin Synnøve; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja Eriksson; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5. 

      Kostenko, Sergiy Viktorovich; Dumitriu, Giania Aurica; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Perturbed action of signal transduction pathways, including the mitogen-activated protein (MAP) kinase pathways, is one of the hallmarks of many cancers. While the implication of the typical MAP kinase pathways ERK1/2-MEK1/2, p38MAPK and JNK is well established, recent findings illustrate that the atypical MAP kinase ERK3/4-MK5 may also be involved in tumorigenic processes. Remarkably, the ERK3/4-MK5 ...

    • Tumour size reduction after the first chemotherapy-course and outcomes of chemoradiotherapy in limited disease small-cell lung cancer 

      Halvorsen, Tarje Onsøien; Herje, Martin; Levin, Nina; Bremnes, Roy M.; Brustugun, Odd Terje; Fløtten, Øystein; Kaasa, Stein; Sundstrøm, Stein Harald; Grønberg, Bjørn Henning (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-15)
      Objectives: <br> Concurrent chemotherapy and thoracic radiotherapy (TRT) is recommended for limited disease small-cell lung cancer (LD SCLC). TRT should start as early as possible, often meaning with the second course due to patient referral time and the fact that TRT planning takes time. Early assessment of response to the first course of chemotherapy may be a useful way to individualise treatment. ...

    • Tumour-suppressor microRNAs let-7 and mir-101 target the proto-oncogene MYCN and inhibit cell proliferation in MYCN-amplified neuroblastoma 

      Buechner, Jochen; Tømte, Ellen; Haug, Bjørn Helge; Henriksen, Jørn Remi; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-06-07)
      BACKGROUND: MicroRNAs (miRNAs) regulate expression of many cancer-related genes through posttranscriptional repression of their mRNAs. In this study we investigate the proto-oncogene MYCN as a target for miRNA regulation.<p> <p>METHODS: A luciferase reporter assay was used to investigate software-predicted miRNA target sites in the 30 -untranslated region (30 UTR) of MYCN. The miRNAs were ...

    • Tuning of Liver Sieve: The Interplay between Actin and Myosin Regulatory Light Chain Regulates Fenestration Size and Number in Murine Liver Sinusoidal Endothelial Cells 

      Zapotoczny, Barlomiej; Szafranska, Karolina; Lekka, Malgorzata; Ahluwalia, Balpreet Singh; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-30)
      Liver sinusoidal endothelial cells (LSECs) facilitate the efficient transport of macromolecules and solutes between the blood and hepatocytes. The efficiency of this transport is realized via transcellular nanopores, called fenestrations. The mean fenestration size is 140 ± 20 nm, with the range from 50 nm to 350 nm being mostly below the limits of diffraction of visible light. The cellular ...

    • Turnover of IPS employment specialists: Rates and predictors 

      Butenko, Daniil; Rinaldi, Miles; Brinchmann, Beate; Killackey, Eoin; Johnsen, Erik; Mykletun, Arnstein (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-15)
      BACKGROUND: There are anecdotal reports of high job turnover of Individual Placement and Support employment specialists. However, no studies have addressed this issue.<p> <p>OBJECTIVE: To explore whether turnover rates among employment specialists are higher compared to public sector employees along with the correlates of turnover intentions. <p>METHODS: A repeated cross-sectional study collected ...

    • Turnuslegers erfaringer med veiledning i turnustjenesten 

      Haugdahl, Hege Selnes; Vikan, Astri; Bjerkeset, Ottar; Hamran, Torunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Den nasjonale spørreundersøkelsen blant turnusleger fra 2007-2008 viste at veiledningen ved sykehuset Levanger var mangelfull. Formålet med denne kvalitative studien var derfor å få en bedre forståelse av turnuslegers erfaringer med veiledning i turnustjenesten. Kvalitative intervju av syv turnusleger som hadde gjennomført turnustjeneste ved sykehuset Levanger i 2007-2008. Erfaringene ble analysert ...

    • Tvang og makt eller normalisering? Ja takk - begge deler. 

      Stavem, Sonja (Master thesis; Mastergradsoppgave, 2011-05-18)
      Bruk av tvang og makt under utøvelsen av sosiale tjenester for mennesker med psykisk utviklingshemming er regulert i kap. 4A i sosialtjenesteloven. Loven ble første gang tatt i bruk som en prøvelov i 1999, og har siden 2004 vært en permanent lov; kap. 4A i Lov om sosiale tjenester. Hvilket syn på mennesker med psykisk utviklingshemming, og hvilken problemforståelse er det som ligger til grunn for ...

    • Tvangshjemler kan føre til mer tvang 

      Riley, Henriette; Storvik, Marius; Hansen, Thomas (Journal article; Tidsskriftartikkel, 2023-03-03)
      En praksis med bruk av tepper, bandasjer, borrelåsstropper eller lignende for å sikre pasienter som motsetter seg under transport, kan være svært inngripende – og gir grunn til bekymring.

    • Tvangsinnleggelser ved en psykiatrisk avdeling, Universitetssykehuset i Nord-Norge 

      Vågan, Audun F. (Master thesis; Mastergradsoppgave, 2002-09)

    • Tverrfaglig poliklinisk behandling av sykelig overvekt 

      Olaisen, Sindre Hellum (Master thesis; Mastergradsoppgave, 2011-09)
      Bakgrunn: Overvektsepidemien skrider frem og rammer stadig flere over hele verden. Verdens helseorganisasjon har innsett alvoret og laget en plan for å forebygge livsstilssykdommer. Det norske Helse- og omsorgsdepartementet har pålagt helseregionene å etablere behandlingstilbud for pasienter med helseproblemer som følge av uttalt overvekt og fedme, og Senter for sykelig overvekt ved Universitetssykehuset ...

    • Tverrprofesjonell praksis utfordrer samarbeidet mellom helsefagstudenter 

      Norbye, Bente (Chapter; Bokkapittel, 2020)
      Dette kapittelet vil synliggjøre studenters erfaringer fra tverrprofesjonell praksis i et aksjonsforskningsprosjekt gjennomført i perioden 2014–2016. Prosjektet hadde som overordnet mål å etablere nye tverrfaglige praksisformer i samarbeid mellom utvalgte helsetjenester og fire profesjonsutdanninger. Prosjektet ble gjennomført i regi av Forskningsgruppa for profesjonsutdanning ved Institutt for helse ...