Cancer remains a major health challenge, with over 19.3 million new cases diagnosed in 2020. Conventional treatments like chemotherapy and radiation face limitations such as toxicity, resistance, and poor targeting. This thesis explores nanomedicine-based immunomodulation strategies, focusing on liposomes to enhance drug delivery to immune cells. Liposomes are nano-sized vesicles that encapsulate ...

For the first time, we have developed a liposomal formulation for Nω-hydroxy-nor-L-arginine (nor-NOHA). nor-NOHA is an arginase inhibitor that has potential in cancer treatment. The work aimed to develop a formulation that would have high encapsulation efficiency (EE%) for nor-NOHA in liposomes. Optimization of liposomes was conducted stepwise, namely liposomal characteristics were investigated ...

Background: The incidence and prevalence of type 2 diabetes mellitus (T2DM) are increasing worldwide. There are several reasons for the growing prevalence, including sedentary lifestyles and increased consumption of unhealthy diets. Inflammation is the immune system’s natural reaction to injury or infection and is suggested to play a key role in the pathogenesis of T2DM. The energy-adjusted dietary ...

Since its introduction, recombinant protein production has opened an important market for industrial applications. While Escherichia coli is undoubtedly the most commonly used bacterium for protein production, its use has limits in the variety of proteins it can successfully produce. One such limitation is the production of cold-adapted proteins. Their high activity at low temperatures and potential ...

Denne masteroppgaven har som formål å undersøke hvitfisknæringens evne til å tilpasse seg endringer skapt av Covid-19. Den strategiske tilpasningsevnen undersøkes ved å se om bedriftene har egenskaper som fleksibilitet for å håndtere de usikre omgivelsene skapt av pandemien. Bransjen som studeres er kjent for å operere under en normaltilstand i turbulente omgivelser. Undersøkelsen har avdekket at ...

Økende etterspørsel etter sjømat stimulerer til innovasjon. Likevel viser flere forsøk på torskeoppdrett uten kommersiell suksess, at oppdrett av marine arter er utfordrende. Med reduserte kvoter på villtorsk er det igjen økt interesse for å etablere seg innen torskeoppdrett. Kunnskapsgrunnlaget er derimot fortsatt svakt og nyetableringer i seg selv innebærer høy risiko. Selv om den gryende næringen ...

Økende befolkningsvekst skaper et økt behov for mat. Et slikt press på de allerede eksisterende ressursene fører til behov for å utnytte enhver ressurs fulle ernæringsmessig potensial. Sjømat blir ansett som en viktig kilde for å imøtekomme dette voksende behovet for økt bærekraftig matsikkerhet. Det er derfor viktig å sikre at alle ressurser som høstes fra havet er av høy kvalitet. En utfordring ...

Rapid climate change significantly impacts high-latitude freshwater ecosystems, altering thermal regimes and ecological dynamics. This study examines the lakes Vaggatem and Skrukkebukta in Pasvik in Northern Norway, where recent decades have seen average increases in surface water temperatures of 0.45°C per decade, accompanied by a modelled 0.07°C decadal rise in hypolimnetic water temperatures, ...

Introduction: Accidental hypothermia is defined as an involuntary drop in core body temperature below 35 °C and is associated with acute cardiac dysfunction. The PDE3 inhibitor milrinone and β-agonist isoprenaline provide positive inotropic effects during normothermia by elevating intracellular levels of cAMP in cardiac cells. Rat models have demonstrated that milrinone has more favorable hemodynamic ...

Jews survived the Second World War in Europe under varied circumstances, and the different ways in which Nazi crimes were shown in the images and texts they produced reflect this diversity. The wide range of cultural activities in the Displaced Persons (DP) camps in the American and British zones of Germany – from visual arts through different forms of literature to theatre and music – attest to the ...