Visible-light photocatalytic double C–H Functionalization of indoles: a synergistic experimental and computational study
ForfatterErdenebileg, Uranbaatar; Demissie, Taye Beyene; Hansen, Jørn H
Herein is disclosed a novel visible-light photocatalytic double C–H functionalization of indoles. The reaction affords 2,3-difunctional- ized indoles in up to 84% yield, but the reaction rate depends strongly on electronic substituent effects. Mechanistic DFT studies and control experiments suggest that the secondary functionalization occurs through an independent photocatalytic oxidation of bromide ions formed during the reaction to generate molecular bromine capable of electrophilic C-3 bromination.
Published version. source at http://dx.doi.org/10.1055/s-0036-1588719