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dc.contributor.authorTryland, Morten
dc.contributor.authorSanchez Romano, Javier
dc.contributor.authorMarcin, Nina
dc.contributor.authorNymo, Ingebjørg Helena
dc.contributor.authorJosefsen, Terje Domaas
dc.contributor.authorSørensen, Karen Kristine
dc.contributor.authorMørk, Torill
dc.date.accessioned2017-08-25T11:57:16Z
dc.date.available2017-08-25T11:57:16Z
dc.date.issued2017-04-24
dc.description.abstractBackground: Infectious keratoconjunctivitis (IKC) is a transmissible disease in semi-domesticated Eurasian reindeer (Rangifer tarandus tarandus). It is regarded as multifactorial and a single causative pathogen has not yet been identified. From clinical outbreaks we have previously identified Cervid herpesvirus 2 (CvHV2) and Moraxella bovoculi as candidates for experimental investigations. Eighteen reindeer were inoculated in the right eye with CvHV2 (n = 5), M. bovoculi (n = 5), CvHV2 and M. bovoculi (n = 5) or sterile saline water (n = 3; controls). <br> Results: All animals inoculated with CvHv2, alone or in combination with M. bovoculi, showed raised body temperature, increased lacrimation, conjunctivitis, excretion of pus and periorbital oedema; clinical signs that increased in severity from day 2 post inoculation (p.i.) and throughout the experiment, until euthanasia 5–7 days p.i. Examination after euthanasia revealed corneal oedema, and three animals displayed a corneal ulcer. CvHV2 could be identified in swab samples from both the inoculated eye and the control eye from most animals and time points, indicating a viral spread from the inoculation site. <br>Conclusions: This study showed that CvHV2 alone and in combination with M. bovoculi was able to cause the characteristic clinical signs of IKC in reindeer, whereas inoculation of M. bovoculi alone, originally isolated from a reindeer with IKC, did not produce clinical signs. Previous studies have suggested that herding procedures, animal stress and subsequent reactivation of latent CvHV2 infection in older animals is a plausible mechanism for IKC outbreaks among reindeer calves and young animals in reindeer herds. However, further studies are needed to fully understand the infection biology and epidemiology associated with IKC in reindeer. Keywords: Alphaherpesvirus, Eye disease, IKC, Moraxella, Ophthalmology, Reindeer, Wildlifeen_US
dc.descriptionSource at <a href=http://dx.doi.org/10.1186/s13028-017-0291-2> http://dx.doi.org/10.1186/s13028-017-0291-2 </a>en_US
dc.identifier.citationTryland M, Sanchez Romano J, Marcin N, Nymo IH, Josefsen TD, Sørensen KK, Mørk T. Cervid herpesvirus 2 and not Moraxella bovoculi caused keratoconjunctivitis in experimentally inoculated semi-domesticated Eurasian tundra reindeer. Acta Veterinaria Scandinavica. 2017;59en_US
dc.identifier.issn1751-0147
dc.identifier.otherFRIDAID 1466640
dc.identifier.other10.1186/s13028-017-0291-2
dc.identifier.urihttps://hdl.handle.net/10037/11386
dc.language.isoengen_US
dc.publisherBioMed Centralen_US
dc.relation.journalActa Veterinaria Scandinavica
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Landbruksfag: 910::Husdyravl, oppdrett, forplantning: 912en_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Agriculture disciplines: 910::Livestock breeding, rearing, reproduction: 912en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Patofysiologi: 721en_US
dc.subjectVDP::Agriculture and fishery disciplines: 900::Clinical veterinary science disciplines: 950en_US
dc.subjectVDP::Landbruks- og Fiskerifag: 900::Klinisk veterinærmedisinske fag: 950en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Physiopathology: 721en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Oftalmologi: 754en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Ophthalmology: 754en_US
dc.titleCervid herpesvirus 2 and not Moraxella bovoculi caused keratoconjunctivitis in experimentally inoculated semi-domesticated Eurasian tundra reindeeren_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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