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dc.contributor.authorTartu, Sabrina
dc.contributor.authorLille-Langøy, Roger
dc.contributor.authorStørseth, Trond Røvik
dc.contributor.authorBourgeon, Sophie
dc.contributor.authorBrunsvik, Anders
dc.contributor.authorGoksøyr, Anders
dc.contributor.authorJenssen, Bjørn Munro
dc.contributor.authorPolder, Anuschka
dc.contributor.authorThiemann, Gregory W.
dc.contributor.authorTorget, Vidar
dc.contributor.authorRoutti, Heli
dc.date.accessioned2017-12-15T13:56:23Z
dc.date.available2017-12-15T13:56:23Z
dc.date.issued2017-11-28
dc.description.abstractThere is growing evidence from experimental and human epidemiological studies that many pollutants can disrupt lipid metabolism. In Arctic wildlife, the occurrence of such compounds could have serious consequences for seasonal feeders. We set out to study whether organohalogenated compounds (OHCs) could cause disruption of energy metabolism in female polar bears ( Ursus maritimus ) from Svalbard, Norway (n = 112). We analyzed biomarkers of energy metabolism including the abundance profiles of nine lipid-related genes, fatty acid (FA) synthesis and elongation indices in adipose tissue, and concentrations of lipid-related variables in plasma (cholesterol, high-density lipoprotein, triglycerides). Furthermore, the plasma metabolome and lipidome were characterized by low molecular weight metabolites and lipid fingerprinting, respectively. Polychlorinated biphenyls, chlordanes, brominated diphenyl ethers and perfluoroalkyl substances were significantly related to biomarkers involved in lipid accumulation, FA metabolism, insulin utilization, and cholesterol homeostasis. Moreover, the effects of pollutants were measurable at the metabolome and lipidome levels. Our results indicate that several OHCs affect lipid biosynthesis and catabolism in female polar bears. Furthermore, these effects were more pronounced when combined with reduced sea ice extent and thickness, suggesting that climate- driven sea ice decline and OHCs have synergistic negative effects on polar bears.en_US
dc.descriptionSource at <a href=http://dx.doi.org/10.1038/s41598-017-16820-5> http://dx.doi.org/10.1038/s41598-017-16820-5 </a>en_US
dc.identifier.citationTartu S, Lille-Langøy R, Størseth TR, Bourgeon S, Brunsvik A, Goksøyr A, Jenssen BM, Polder A, Thiemann GW, Torget V, Routti H. Multiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bears. Scientific Reports. 2017;7en_US
dc.identifier.issn2045-2322
dc.identifier.otherFRIDAID 1519516
dc.identifier.other10.1038/s41598-017-16820-5
dc.identifier.urihttp://hdl.handle.net/10037/11870
dc.language.isoengen_US
dc.publisherNature Publishing Groupen_US
dc.relation.journalScientific Reports
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi: 489en_US
dc.subjectVDP::Mathematics and natural science: 400::Zoology and botany: 480::Ecotoxicology: 489en_US
dc.titleMultiple-stressor effects in an apex predator: combined influence of pollutants and sea ice decline on lipid metabolism in polar bearsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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