Institutt for farmasi: Nye registreringer

Viser treff 581-600 av 706

    • Controlling Antimicrobial Resistance through Targeted, Vaccine-Induced Replacement of Strains 

      Tekle, Yonas I.; Nielsen, Kaare Magne; Liu, Jingzhou; Pettigrew, Melinda M.; Meyers, Lauren A.; Galvani, Alison P.; Townsend, Jeffrey P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Vaccination has proven effective in controlling many infectious diseases. However, differential effectiveness with regard to pathogen genotype is a frequent reason for failures in vaccine development. Often, insufficient immune response is induced to prevent infection by the diversity of existing serotypes present in pathogenic populations of bacteria. These vaccines that target a too narrow spectrum ...

    • Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival 

      Slipicevic, Ana; Holm, Ruth; Emilsen, Elisabeth; Rosnes, Anne Katrine Ree; Welch, Danny R.; Mælandsmo, Gunhild; Flørenes, Vivi Ann (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Breast cancer metastasis suppressor 1 (BRMS1) blocks metastasis in melanoma xenografts; however, its usefulness as a biomarker in human melanomas has not been widely studied. The goal was to measure BRMS1 expression in benign nevi, primary and metastatic melanomas and evaluate its impact on disease progression and prognosis. Paraffin-embedded tissue from 155 primary melanomas, 69 metastases and 15 ...

    • Expression of S100A4, ephrin-A1 and osteopontin in non-small cell lung cancer 

      Rud, Ane Kristine Kongsgaard; Lund-Iversen, Marius; Berge, Gisle; Brustugun, Odd Terje; Solberg, Steinar; Mælandsmo, Gunhild; Pedersen, Kjetil Boye (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these biomarkers in primary tumor tissue from NSCLC patients. Four NSCLC cell lines were treated ...

    • A Trade-off between the Fitness Cost of Functional Integrases and Long-term stability of Integrons 

      Starikova, Irina; Harms, Klaus; Haugen, Pål; Lunde, Tracy Munthali; Primicerio, Raul; Samuelsen, Ørjan; Nielsen, Kaare Magne; Johnsen, Pål Jarle (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Horizontal gene transfer (HGT) plays a major role in bacterial microevolution as evident from the rapid emergence and spread of antimicrobial drug resistance. Few studies have however addressed the population dynamics of newly imported genetic elements after HGT. Here, we show that newly acquired class-1 integrons from Salmonella enterica serovar Typhimurium and Acinetobacter baumannii, free of ...

    • Use of 3-D modelling in early development phase of pectin tablets 

      Salbu, Linda; Picker-Freyer, Katharina M.; Schmid, Wolfgang; Bauer-Brandl, Annette; Tho, Ingunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      This study examines the contribution of the 3-D model in an early development set-up for pectin tablets. Therefore, the aim of this work is to extract as much information on the compression behaviour from as few tablets as possible. Pectins with various degrees of methoxylation (DM) were studied (4-72%). The compressibility was evaluated by classical “in-die” Heckel and Kawakita analyses in addition ...

    • Ultrasound-mediated destabilization and drug release from liposomes comprising dioleoylphosphatidylethanolamine 

      Evjen, Tove Julie; Nilssen, Esben A.; Barnert, Sabine; Schubert, Rolf; Brandl, Martin; Fossheim, Sigrid L (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Novel sonosensitive doxorubicin-containing liposomes comprising dioleoylphosphatidylethanolamine (DOPE) as the main lipid constituent were developed and characterized in terms of ultrasound-mediated drug release in vitro. The liposome formulation showed high sonosensitivity; where approximately 95% doxorubicin was released from liposomes after 6 min of 40 kHz US exposure in buffered sucrose solution. ...

    • Karakterisering og optimalisering av myke omega-3-kapsler med kalsium : et prosjekt i sammarbeid med ProBio Neutraceuticals AS/Ayanda 

      Tendeland, Judit Chipo (Master thesis; Mastergradsoppgave, 2009-05-20)
      For omega-3-kapsler med kalsiumkarbonat ble det observert problemer med dannelse av brune flekker som misfarget det hvite kapselskallet en viss tid etter produksjon. Produktet er myke suspendert i fyllmaterialet. Av visuelle årsaker er denne suspensjonen maskert ved å tilsette titaniumdioksid som fargestoff i gelatinkapselskallet. En hypotese er at misfargingen skyldes lekkasje av fiskeolje fra ...

    • Isolering og karakterisering av antibakterielle forbindelser i sjøstjernene: Urasterias linckii, Solaster endeca og Crossaster papposus 

      Ngo, Thong Huu (Master thesis; Mastergradsoppgave, 2009-06)
      Antibakteriell aktivitet mot Gram positive og Gram negative bakterier er påvist i ekstrakter av celler og plasma fra Solaster endeca, Crossaster papposus og Urasterias Linckii. Det har også blitt påvist antibakteriell aktivitet mot Gram negative bakterier i ekstrakter av hel kropp fra Solaster endeca og Croassaster papposus. Materialet ble grovekstrahert med 60 % Acetonitril, videre ble vannfase og ...

    • Isolering og karakterisering av forbindelser med anticancereffekt fra tre ulike marine organismer 

      Jalal, Shwan Hiwa (Master thesis; Mastergradsoppgave, 2010-06-16)
      Marin bioprospektering er i hurtig fremmarsj både i Norge og på verdensbasis. Det kan defineres som en formålrettet og systematisk leting etter bestander, bioaktive forbindelser eller gener i marine organismer med sikte på utvikling av et produkt som er kommersielt eller samfunnsmessige viktige. Målet med denne oppgaven er å lete etter forbindelser med anticancereffekt i ekstrakter av tre ulike ...

    • Identifisering av en gruppe glykosyltransferaser som mulige målgener for transkripsjonsfaktoren Pax6 

      Nguyen, Huong-Lan Thi (Master thesis; Mastergradsoppgave, 2009-11-09)
      Det har vært stadig mer forskning på rollen av glykosylering i utvikling av sykdommer i de siste tiårene. Glykosylering av proteiner er en prosess hvor karbohydrat grupper overføres til et protein ved hjelp av glykosyltransferaser. Denne prosessen er nødvendig for riktig folding av proteiner som gir riktig funksjon til ulike proteiner. Endringer i glykosylering av proteiner har vist å ha sammenheng ...

    • Identifisering av PAX- og MMP-uttrykk i tre prostatakreft-cellelinjer 

      Weibust, Elisabeth (Master thesis; Mastergradsoppgave, 2009-05-20)
      Invasjon og metastasering er den vanligste årsaken til død hos kreftpasienter og dermed et alvorlig klinisk problem. Det er derfor viktig å forske på dette området for å finne mekanismene bak disse prosessene. Matriks metalloproteinaser (MMPer) er overuttrykt i flere kreftformer. PAX6 er en transkripsjonsfaktor som er vist å regulere matriks metalloproteinase 2 og 9 (MMP-2 og MMP-9) i henholdsvis ...

    • Isolation and characterization of antiviral compounds from marine organisms 

      Ammari, Yashar (Master thesis; Mastergradsoppgave, 2010-06-16)
      Metridium senile, Halocynthia pyriformis and ParaParastichopus tremulus were subjected to organic and aqueous extraction. The aqueous extract was made with water, while the organic was made with dichloromethane and methanol in 1:1 ratio. The aqueous and organic extracts were fractionated on reversed-phase HPLC and tested for antiviral activity against Herpes simplex virus-1. All the three organisms ...

    • Isolation and characterization of antibacterial compounds from marine organisms 

      Thanki, Meera Satish (Master thesis; Mastergradsoppgave, 2010-06-17)
      Marine bioprospecting is a promising field of research that has gained interest worldwide for the past few decades, and can be characterised as a systematic and purpose oriented search for bioactive compounds or genetic material from marine sources. Several compounds have been isolated and some have found their way into the commercial market. The main aim of this master thesis was to investigate the ...

    • Ampicillin resistance and bacterial diversity in colon content from grey seals (Halichoerus grypus) and harbour seals (Phoca vitulina) at the coast of Northern Norway 

      Kristiansen, Vibeke Fam (Master thesis; Mastergradsoppgave, 2007-05)
      Very little is known on the gut microbial ecology in seals. Environmental populations of bacteria, like those found in the gut of wildlife presumably unexposed to human antibiotic use, may be a reservoir of clinically important resistance genes. The purpose of this study was to characterize the bacterial diversity in the colon of grey seals (Halichoerus grypus) and harbour seals (Phoca vitulina) at ...

    • Lipidklasser og fettsyresammensetning i omega-3 produkter 

      Eriksen, Sureeporn Aemsangthum (Master thesis; Mastergradsoppgave, 2012-05-20)
      Nasjonalt råd for ernæring anbefaler å spise fisk og sjømat fordi de innholder de flerumettede omega-3 fettsyrene eikosapentaensyre (EPA: 20:5n-3) og dokosahekaensyre (DHA: 22: 6n-3). Mye forskning viser kobling mellom omega-3 fettsyrene og helsegevinster. Helsegevinstene er at disse fettsyrene er betennelsesdempende, de reduserer risiko for å utvikle sykdommer som revmatoid artritt, hjerte -kar ...

    • Isolation and characterization of anti-inflammatory compounds from marine organisms : Eucratea loricata and Echinus esculentus 

      Do, Minh-Anh Thuy (Master thesis; Mastergradsoppgave, 2012-05-19)
      In the last decade, the investigation of marine natural products has resulted in a remarkable number of compounds with promising biological activities. Marine natural products have been shown to display antibacterial, antifungal, anticancer, antiviral, antiparasitic, anti-inflammatory activity and several other pharmacological activities of benefit to humankind. In this project, an investigation ...

    • Evaluation of a pharmacist-led cardiovascular risk clinic for patients with diabetes attending a hospital out-patient clinic 

      Majid Alwan, Ahmed (Master thesis; Mastergradsoppgave, 2012-06-11)
      Cardiovascular disease is strongly associated with diabetes; hypertension is prominent in diabetic patients. In 2003 a pharmacist-led cardiovascular risk reduction clinic was established to reduce cardiovascular risk in diabetic patients. The aim of this study was to evaluate the feasibility of outcome measures to inform a future prospective study to evaluate the pharmacist-led clinic and to ...

    • Development of bioactive peptides from the parasitic hookworm as potential treatments for autoimmune diseases 

      Baumann, Markus (Master thesis; Mastergradsoppgave, 2012-06)
      Hookworms are parasitic nematodes that reside in the intestines of their host, where they feed on host blood. The large number of infected individuals and the long survival time inside the host makes it interesting to study the immunomodulatory activities of the hookworms. The excretory/secretory (ES) products are suspected to be responsible for these effects. One aim of this project was to fractionate ...

    • Review and development of referral criteria used to identify patients with diabetes who would benefit from attending a pharmacist-led cardiovascular out-patient clinic 

      Westerhus, Ingvild Risan (Master thesis; Mastergradsoppgave, 2012-05)
      Abstract Development and validation of new referral criteria: a triangulation study at the Pharmacist-led Diabetes Cardiovascular risk Reduction Clinic, Edinburgh. The Pharmacist-led Diabetes Cardiovascular risk Reduction (DCVR) clinic has been running at the Western General Hospital (WGH), Edinburgh, for 8 years. It was decided to review the referral process of patients and the referral criteria. ...

    • LC-MS basert analysemetode av gentamicin i blodprøver 

      Haug, Marianne Helene Christiansen (Master thesis; Mastergradsoppgave, 2012-05-20)
      Gentamicin er hyppig brukt til å behandle alvorlige infeksjoner, men kan ved langvarig behandling eller ved høy serumkonsentrasjon gi vevsskade i både nyrer og ører. Måling av serumkonsentrasjonen skjer rutinemessig med en immunologisk metode som krever et blodvolum på 500 µl. Hyppige målinger er i noen tilfeller nødvendig for å få god kontroll på behandlingen. Premature barn har lav kroppsvekt og ...