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dc.contributor.authorHammond, John S.
dc.contributor.authorGodtliebsen, Fred
dc.contributor.authorSteigen, Sonja Eriksson
dc.contributor.authorGuha, I. Neil
dc.contributor.authorWyatt, Judy
dc.contributor.authorRevhaug, Arthur
dc.contributor.authorLobo, Dileep N.
dc.contributor.authorMortensen, Kim Erlend
dc.date.accessioned2019-12-30T12:08:22Z
dc.date.available2019-12-30T12:08:22Z
dc.date.issued2019-01-15
dc.description.abstractLiver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis, and when PVP is reduced, rates of liver dysfunction decrease. The aim of the present study was to characterize the hemodynamic, biochemical, and histological changes induced by 80% hepatectomy in non-cirrhotic pigs and determine if terlipressin or direct portacaval shunting can modulate these effects. Pigs were randomized (n=8/group) to undergo 80% hepatectomy alone (control); terlipressin (2 mg bolus + 0.5–1 mg/h) + 80% hepatectomy; or portacaval shunt (PCS) + 80% hepatectomy, and were maintained under terminal anesthesia for 8 h. The primary outcome was changed in PVP. Secondary outcomes included portal venous flow (PVF), hepatic arterial flow (HAF), and biochemical and histological markers of liver injury. Hepatectomy increased PVP (9.3 ± 0.4 mmHg pre-hepatectomy compared with 13.0 ± 0.8 mmHg post-hepatectomy, P<0.0001) and PVF/g liver (1.2 ± 0.2 compared with 6.0 ± 0.6 ml/min/g, P<0.0001) and decreased HAF (70.8 ± 5.0 compared with 41.8 ± 5.7 ml/min, P=0.002). Terlipressin and PCS reduced PVP (terlipressin = 10.4 ± 0.8 mmHg, P=0.046 and PCS = 8.3 ± 1.2 mmHg, P=0.025) and PVF (control = 869.0 ± 36.1 ml/min compared with terlipressin = 565.6 ± 25.7 ml/min, P<0.0001 and PCS = 488.4 ± 106.4 ml/min, P=0.002) compared with control. Treatment with terlipressin increased HAF (73.2 ± 11.3 ml/min) compared with control (40.3 ± 6.3 ml/min, P=0.026). The results of the present study suggest that terlipressin and PCS may have a role in the prevention and treatment of post-resection liver failure.en_US
dc.identifier.citationHammond, Godtliebsen F, Steigen SE, Guha, Wyatt, Revhaug A, Lobo DN, Mortensen KE. The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig. Clinical Science. 2019;133(1):153-166en_US
dc.identifier.cristinIDFRIDAID 1666266
dc.identifier.doi10.1042/CS20180858
dc.identifier.issn0143-5221
dc.identifier.issn1470-8736
dc.identifier.urihttps://hdl.handle.net/10037/16995
dc.language.isoengen_US
dc.publisherPortland Pressen_US
dc.relation.journalClinical Science
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2019 The Author(s)en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.rightsAttribution 4.0 International*
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Gastroenterology: 773en_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gasteroenterologi: 773en_US
dc.titleThe effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pigen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as Attribution 4.0 International