ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraakEnglish 
    • EnglishEnglish
    • norsknorsk
  • Administration/UB
View Item 
  •   Home
  • Fakultet for biovitenskap, fiskeri og økonomi
  • Institutt for arktisk og marin biologi
  • Artikler, rapporter og annet (arktisk og marin biologi)
  • View Item
  •   Home
  • Fakultet for biovitenskap, fiskeri og økonomi
  • Institutt for arktisk og marin biologi
  • Artikler, rapporter og annet (arktisk og marin biologi)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

DNA double‐strand breaks in Arctic char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arctic

Permanent link
https://hdl.handle.net/10037/17735
DOI
https://doi.org/10.1002/etc.4546
Thumbnail
View/Open
article.pdf (288.1Kb)
Published version (PDF)
Date
2019-07-25
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Author
Neerland, Eirik D.; Bytingsvik, Jenny; Nikiforov, Vladimir; Evenset, Anita; Krøkje, Åse
Abstract
High levels of organochlorine contaminants (OCs) have been found in arctic char (Salvelinus alpinus) from Lake Ellasjøen, Bjørnøya (Norwegian Arctic). The aim of the present study was to investigate the potential genotoxic effect of environmental organochlorine contaminant exposure in arctic char from Ellasjøen compared with arctic char from the low‐contaminated Lake Laksvatn nearby. Blood was analyzed using agarose gel electrophoresis and image data analysis to quantify the fraction of total DNA that migrated into the gel (DNA‐FTM) as a relative measure of DNA double‐strand breaks (DSBs). Analysis by GC‐MS of muscle samples showed an average 43 times higher concentration of ΣOCs in arctic char from Ellasjøen (n = 18) compared with Laksvatn char (n = 21). Char from Lake Ellasjøen had a much higher frequency of DSBs, as measured by DNA‐FTM, than char from Lake Laksvatn. Principal component analysis and multiple linear regressions show that there was a significant positive relationship between DSBs and levels of organochlorine contaminants in the char. In addition, DSBs were less frequent in reproductively mature char than in immature char. The results suggest that organochlorine contaminants are genotoxic to arctic char.
Publisher
Wiley
Citation
Neerland, Bytingsvik J, Nikiforov V, Evenset A, Krøkje Å. DNA double‐strand breaks in Arctic char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arctic. Environmental Toxicology and Chemistry. 2019;38(11):2405-2413
Metadata
Show full item record
Collections
  • Artikler, rapporter og annet (arktisk og marin biologi) [1635]
Copyright 2019 The Author(s)

Browse

Browse all of MuninCommunities & CollectionsAuthor listTitlesBy Issue DateBrowse this CollectionAuthor listTitlesBy Issue Date
Login

Statistics

View Usage Statistics
UiT

Munin is powered by DSpace

UiT The Arctic University of Norway
The University Library
uit.no/ub - munin@ub.uit.no

Accessibility statement (Norwegian only)