ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraaknorsk 
    • EnglishEnglish
    • norsknorsk
  • Administrasjon/UB
Vis innførsel 
  •   Hjem
  • Fakultet for biovitenskap, fiskeri og økonomi
  • Institutt for arktisk og marin biologi
  • Artikler, rapporter og annet (arktisk og marin biologi)
  • Vis innførsel
  •   Hjem
  • Fakultet for biovitenskap, fiskeri og økonomi
  • Institutt for arktisk og marin biologi
  • Artikler, rapporter og annet (arktisk og marin biologi)
  • Vis innførsel
JavaScript is disabled for your browser. Some features of this site may not work without it.

DNA double‐strand breaks in Arctic char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arctic

Permanent lenke
https://hdl.handle.net/10037/17735
DOI
https://doi.org/10.1002/etc.4546
Thumbnail
Åpne
article.pdf (288.1Kb)
Publisert versjon (PDF)
Dato
2019-07-25
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Neerland, Eirik D.; Bytingsvik, Jenny; Nikiforov, Vladimir; Evenset, Anita; Krøkje, Åse
Sammendrag
High levels of organochlorine contaminants (OCs) have been found in arctic char (Salvelinus alpinus) from Lake Ellasjøen, Bjørnøya (Norwegian Arctic). The aim of the present study was to investigate the potential genotoxic effect of environmental organochlorine contaminant exposure in arctic char from Ellasjøen compared with arctic char from the low‐contaminated Lake Laksvatn nearby. Blood was analyzed using agarose gel electrophoresis and image data analysis to quantify the fraction of total DNA that migrated into the gel (DNA‐FTM) as a relative measure of DNA double‐strand breaks (DSBs). Analysis by GC‐MS of muscle samples showed an average 43 times higher concentration of ΣOCs in arctic char from Ellasjøen (n = 18) compared with Laksvatn char (n = 21). Char from Lake Ellasjøen had a much higher frequency of DSBs, as measured by DNA‐FTM, than char from Lake Laksvatn. Principal component analysis and multiple linear regressions show that there was a significant positive relationship between DSBs and levels of organochlorine contaminants in the char. In addition, DSBs were less frequent in reproductively mature char than in immature char. The results suggest that organochlorine contaminants are genotoxic to arctic char.
Forlag
Wiley
Sitering
Neerland, Bytingsvik J, Nikiforov V, Evenset A, Krøkje Å. DNA double‐strand breaks in Arctic char (Salvelinus alpinus) from Bjørnøya in the Norwegian Arctic. Environmental Toxicology and Chemistry. 2019;38(11):2405-2413
Metadata
Vis full innførsel
Samlinger
  • Artikler, rapporter og annet (arktisk og marin biologi) [1636]
Copyright 2019 The Author(s)

Bla

Bla i hele MuninEnheter og samlingerForfatterlisteTittelDatoBla i denne samlingenForfatterlisteTittelDato
Logg inn

Statistikk

Antall visninger
UiT

Munin bygger på DSpace

UiT Norges Arktiske Universitet
Universitetsbiblioteket
uit.no/ub - munin@ub.uit.no

Tilgjengelighetserklæring