Skagseth, Susann; Akhter, Sundus; Paulsen, Marianne H; Muhammad, Zeeshan; Samuelsen, Ørjan; Leiros, Hanna-Kirsti S.; Bayer, Annette (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-14)
Bacterial resistance is compromising the use of β-lactam antibiotics including carbapenems. The
main resistance mechanism against β-lactams is hydrolysis of the β-lactam ring mediated by
serine- or metallo-β-lactamases (MBLs). Although several inhibitors of MBLs have been
reported, none has been developed into a clinically useful inhibitor. Mercaptocarboxylic acids
are among the most prominent ...