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  • Characterization of a neuraminic acid synthase from the psychrophilic organism Moritella viscosa 

    Berg, Tor Olav (Master thesis; Mastergradsoppgave, 2013-05-15)
    Sialic acids are family of nine carbon α-keto acids found to have important roles mammals and bacteria. They are negatively charged sugars which have found to play critical roles in the cognitive development, as well as being a part of the innate immune system and being targets for pathogens. Mammalian cells express sialic acids to confer self to the immune system, a trait being exploited by some ...
  • Studies Towards the Synthesis of DKP Analogues. Investigations of Bis-lactim Ether Reactivity with Aldehydes and Ketones 

    Kadysjev, Arslan Maratovitsj (Master thesis; Mastergradsoppgave, 2016-05-19)
    A group of molecules with the name diketopiperazines (DKP) are called so, because of their diketopiperazine ring as the core structural unit. Mainly there are 3 types of diketopiperazies which only differ in in the position of the keto group, one type has the keto groups in 2,3- position; another in 2,5-; and the third in 2,6- position. The 2,5- isomer has attracted great interest, because of compounds ...
  • Characterization and structural analysis of class D β-lactamases: variants and mutants of OXA-type carbapenemases 

    Nesheim, Birgit Helene Berg (Master thesis; Mastergradsoppgave, 2016-05-18)
    The rise and spread of antibiotic resistant bacteria is posing a serious threat to the global health; antibiotic drugs are rendered ineffective and common infectious diseases become harder or impossible to treat. The beta-lactamase enzymes, with their ability to hydrolyze the beta-lactam antibiotics, are a major cause of resistant bacteria. The OXA-beta-lactamase enzymes are one of the most alarming ...
  • An Insight into the Aliivibrio genus. A comparative study on relationships and traits of species within the genus Aliivibrio 

    Klemetsen, Terje (Master thesis; Mastergradsoppgave, 2016-05-18)
    Few studies have emphasized on the genus Aliivibrio as a whole and lags behind the better known Vibrio. Nevertheless, the Aliivibrio has for several decades been associated with species expressing bioluminescence like the Aliivibrio fischeri, but has also been linked to costly diseases in the fish farming industry such as Aliivibrio salmonicida. In an attempt to gain insight in the genus on a ...
  • Vertical Diversity-Oriented Synthesis with Dibenzylideneacetones. Multivariate Optimization and Diversity Exploration. 

    Buhire, Phenias (Master thesis; Mastergradsoppgave, 2015-05-18)
    DOS was planned from dibenzylideneacetone to generate compound library with structural diversity, which can undergo further transformations. In the presented work, dibenzylideneacetone was cyclized under Robinson Annulation reaction. The resulting cyclization product was optimized using Multivariate response surface method. Response surface analysis helped to determine both significant variables ...
  • On the Synthesis of Breitfussins. Toward the total synthesis of Breitfussin A and analogues 

    Guttormsen, Yngve (Master thesis; Mastergradsoppgave, 2014-05)
    The Breitfussins are a series of closely related heterocyclic compounds originated from the marine organism Thelia Breitfussi. The core is a 5(indol-3-yl)-2-(pyrrol-2-yl)oxazole, which has not been observed prior to its isolation in 2007. The divergence of the Breitfussins lies in the halogenation pattern and methoxy substitution. Breitfussin A is of synthetic interest because of its novel structural ...
  • MD simulations reveal how synthetic antimicrobial peptides interact with membrane models 

    Sarre, Birta Ravdna (Master thesis; Mastergradsoppgave, 2014-12-17)
    Since the discovery of antibiotics the extensive use in health care and agriculture has led to the development of resistant bacterial strains. Antimicrobial peptides (AMPs) exists in nature where they are believed to play an important role in the innate immune system in vertebrates. Due to their antibacterial properties and apparent ability to elicit very low bacterial resistance, researchers have ...
  • Target characterization and ligand design directed at deoxyuridine 5'-triphospate nucleotidohydrolase 

    Liikanen, Laura Elina (Master thesis; Mastergradsoppgave, 2014-07-01)
    dUTPase is an important enzyme in DNA metabolism. It can be thought of as a gate keeper for apoptosis and is therefore an attractive target when trying to kill malign cells which cause disease in the human body. dUTPase has been found to be an important drug target in diseases such as cancer and malaria, to mention two. Due to problems with drug resistance in existing treatments, the search for new ...
  • Biophysical characterization of the DYRK family. Studies on the kinases DYRK1A and DYRK1B 

    Alexeeva, Marina (Master thesis; Mastergradsoppgave, 2013-11-13)
    The dual-specificity tyrosine phosphorylation-regulated kinase family (DYRKs) has recently emerged as new therapeutic targets for different kinds of cancer and neurodegenerative diseases. In the latest studies it was shown that DYRK1B plays a key role in cancer cell survival, and its inhibition induces apoptosis of cancer cells. This thesis is about the biophysical characterization of DYRK1B and ...
  • Identification, cloning and expressions of proteases from a cold adapted organism Aliivibrio salmonicida 

    Ather, Arjumand (Master thesis; Mastergradsoppgave, 2009-07-27)
    The work presented in this thesis provides an overview of molecular and structural biology projects and their related problems. The problems arises during these projects are common for most of the target proteins, with varying intensity of severity. The realization and identification of these problems and selection of their correct, best possible solution is an imperative step that might lead to ...
  • Reductions of barbituric acid based compounds 

    Kristoffersen, Stian (Master thesis; Mastergradsoppgave, 2013-05-15)
    Reductions of chalconoids with different para- substituents on the phenyl ring have been investigated in order to screen for kinase inhibitors with improved properties.
  • Synthesis of β-substituted β-aminoboronates 

    Thomassen, Ivar Kristian (Master thesis; Mastergradsoppgave, 2013-05)
    Recent work at the University of Tromsø has uncovered new α-substituted α- and β-aminoboron containing peptidomimetics that shows antimicrobial, antifungal and antitubercular activity in addition to kinase inhibition and promotion. As a continuation of this work a new approach for the synthesis of β-substituted β-aminoboronates has been developed. The approach involves the non-stereospecific ...
  • Biotech applications of protein kinase affinity interactions 

    Lund, Bjarte Aarmo (Master thesis; Mastergradsoppgave, 2013-05)
    Protein kinases provide one of the cell’s most important methods for signaling and control. 2% of the encoding genome consists of protein kinase genes, and from 10-50% of the proteins in the cell are phosphorylated at some point in the cell cycle. Malfunction of protein kinases is connected to several disease-conditions, most prominently cancer, Alzheimer’s and diabetes. Understanding the ...
  • Karakterisering av kommersielle omega-3 produkter og utvikling av en ny metode for separasjon av lipidklasser med fast-fase ekstraksjon 

    Ovesen, Marte Stokvik (Master thesis; Mastergradsoppgave, 2012-11-15)
    Kliniske studier viser at inntak av omega-3 fettsyrene EPA, DPA og DHA kan bidra til å forebygge hjerte- og karsykdommer, redusere inflammasjon, påvirke sentralnervesystemets funksjon positivt og bidra til en rekke andre helsegevinster. Som en konsekvens har markedet for kommersielle omega-3 produkter økt de siste tiårene. Det ble kjøpt inn 10 produkter til dette studiet. Produktene baserte seg på ...
  • Inhibition study of Vibrio cholerae Endonuclease I 

    Sivertsen, Annfrid (Master thesis; Mastergradsoppgave, 2008-05-15)
    The Vibrio cholerae bacteria resistance against introduction of new genetic material through transformation is caused mainly by a small extracellular or periplasmic endonuclease of type I, the VcEndA of 24.7 kDa coded by the dns gene, (Focareta et al, 1987; Focareta et al, 1991; Altermark et al, 2007b). The VcEndA homologues in other bacteria, Serratia marcescens (Timmins et al, 1973), Erwinia ...
  • A new fluorous-tagged porphyrinoid 

    Larsen, Simon (Master thesis; Mastergradsoppgave, 2012-08-16)
    The field of corrole chemistry has flourished over the past decade. Simple and high-yielding procedures have made the corrole ligand readily available, and several procedures on how to functionalize and otherwise modify corroles and their metal complexes have been reported. During an attempt to synthesize corrole from a fluorous tagged aromatic aldehyde a new porphyrinoid has been isolated from ...
  • Ring closing reactions of barbituric acid derivatives 

    Kasiulis, Evaldas (Master thesis; Mastergradsoppgave, 2012-06-08)
    Ring closing reactions of barbituric acid derivatives
  • Attempted syntheses of 1,3,4,6-tetrasubstituted-2,5-diketopiperazines using microwave assisted heating 

    Grineviciute, Laima (Master thesis; Mastergradsoppgave, 2012-06-08)
    Attempted syntheses of 1,3,4,6-tetrasubstituted-2,5-diketopiperazines using microwave assisted heating
  • Site-directed mutagenesis of the metallo-β-lactamase VIM-7 from the opportunistic human pathogenic bacteria Pseudomonas aeruginosa 

    Skagseth, Susann (Master thesis; Mastergradsoppgave, 2012-05-15)
    The metallo-β-lactamases (MBLs) are enzymes with the ability to hydrolyse the β-lactam antibiotics. The worldwide emergence of the antibiotic resistant MBLs poses an increasing clinical threat. The VIM enzymes are a growing family of carbapenemases with a wide geographic distribution in Europe, South America and the USA. The VIM-7, the first VIM enzyme to be discovered in the USA, is the most divergent ...
  • Protein-protein binding affinities calculated using the LIE method 

    Andberg, Tor Arne Heim (Master thesis; Mastergradsoppgave, 2011-11-15)
    Absolute binding free energies for the third domain of the turkey ovomucoid inhibitor in complex with Streptomyces griseus proteinase B and porcine pancreatic elastase has been calculated using the linear interaction energy method.

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