Recent additions

  • Exploring N-nucleophiles for diversification of a complex cyclohexenone scaffold 

    Brevik, Erlend Christopher (Master thesis; Mastergradsoppgave, 2019-06-05)
    In this thesis, synthesis of 3 different dibenzylideneacetone (DBA)-analogues and 4 different ethyl 2-oxo-6-phenyl-4-(2-phenylethenyl)-4-cyclohexene-1-carboxylate-analogues that have not been reported before were synthesized, as well as a range of analogues that have been reported before. Both symmetrical and unsymmetrical DBA-analogues were made. The yields of many of these reactions were low, but ...
  • Structure activity investigations of XTH inhibitors 

    Kosonen, Juho Aleksi (Master thesis; Mastergradsoppgave, 2019-05-15)
    XTHs (xylogclucan endotransglucosylase/hydrolases) are a group of plant enzymes that regulate xyloglucan crosslinking in cell walls and play an essential role in regulation of plant growth. It is thought that XTHs play an integral role in the way the parasitic vine plant Cuscuta is able to penetrate host plant cell walls. Parasitic higher plants are a formidable threat to agricultural production ...
  • Development of a novel method for the analysis of acyl carnitine profile using liquid chromatography mass spectrometry 

    Spickova, Hana (Master thesis; Mastergradsoppgave, 2019-05-15)
    Carnitine is a low-molecular-weight compound that has an obligate role in the mitochondrial oxidation of long-chain fatty acids (acyl groups) and energy production. Therefore, acylcarnitines are essential diagnostic markers for complex diseases, fatty acid metabolism disorders, and disorders related to amino acids metabolism. Biochemical screening of the acylcarnitine profile is performed in clinical ...
  • Synthesis of XTH inhibitors 

    Pettersen, Martin (Master thesis; Mastergradsoppgave, 2019-05-15)
    XTH er en gruppe enzymer som ble oppdaget tidlig på 90 tallet og muligens er involvert i Cuscuta infeksjonen av tomater. En nylig studie gjort ved arktisk og marin biologi UIT viser at Brilliant Blue R250 fungerer som en god inhibitor mot disse enzymene. I dette prosjektet ble det fokusert på å syntetisere strukturelt like molekyler for å potensielt øke vannløseligheten og inhibitoraktiviteten. ...
  • Rhenium- and technetium-oxo corroles: Toward corrole-based drugs and radiopharmaceuticals. 

    Einrem, Rune Finsås (Master thesis; Mastergradsoppgave, 2017-11-15)
    Corroles are an important class of contracted porphyrin analogues. Since quasi-one-pot syntheses of corroles were first reported in 1999, their coordination chemistry has been extensively studied. In the course of this thesis, the “periodic table of corroles” has been extended by two new elements, rhenium and technetium. Except from an accidental synthesis of an ReVO corrole via ring contraction ...
  • Synthesis of phorbazoles and breitfussins analogues 

    Abdelhady, Ahmed Mossad Mohamed (Master thesis; Mastergradsoppgave, 2016-05-18)
    Breitfussins are a group of a closely related heterocyclic compounds. They consist of a tetracyclic structure with an indole, an oxazole and a pyrrole. The breitfussins exhibit interesting biological activity and analogues synthesis and biological evaluation is ongoing. Phorbazoles have a structural similarity with breitfussins in which a phenol replaces the indole. As a part of this, synthesis of ...
  • Enzyme mechanism, thermostability, and structural studies of OXA-48 like carbapenemases involved in antibiotic resistance 

    Thomassen, Ane Molden (Master thesis; Mastergradsoppgave, 2018-05-15)
    Antibiotic resistance is being recognized as a world-wide crisis in modern medicine, rapidly outpacing available treatment options. The serine-beta-lactamase OXA-48 was first identified from a carbapenem- and multidrug- resistant Klebsiella pneumoniae isolate in Turkey in 2001, and is now one of the most geographically widespread members of the class D beta-lactamases. OXA-48 like beta-lactamases ...
  • Solvent effect with Multiwavelets 

    Monstad, Rune Sørland (Master thesis; Mastergradsoppgave, 2017-11-15)
    This thesis contains the inclusion of solvent effect in the computational chemistry program MRChem. Water in water systems are of importance.
  • Characterization of a neuraminic acid synthase from the psychrophilic organism Moritella viscosa 

    Berg, Tor Olav (Master thesis; Mastergradsoppgave, 2013-05-15)
    Sialic acids are family of nine carbon α-keto acids found to have important roles mammals and bacteria. They are negatively charged sugars which have found to play critical roles in the cognitive development, as well as being a part of the innate immune system and being targets for pathogens. Mammalian cells express sialic acids to confer self to the immune system, a trait being exploited by some ...
  • Studies Towards the Synthesis of DKP Analogues. Investigations of Bis-lactim Ether Reactivity with Aldehydes and Ketones 

    Kadysjev, Arslan Maratovitsj (Master thesis; Mastergradsoppgave, 2016-05-19)
    A group of molecules with the name diketopiperazines (DKP) are called so, because of their diketopiperazine ring as the core structural unit. Mainly there are 3 types of diketopiperazies which only differ in in the position of the keto group, one type has the keto groups in 2,3- position; another in 2,5-; and the third in 2,6- position. The 2,5- isomer has attracted great interest, because of compounds ...
  • Characterization and structural analysis of class D β-lactamases: variants and mutants of OXA-type carbapenemases 

    Nesheim, Birgit Helene Berg (Master thesis; Mastergradsoppgave, 2016-05-18)
    The rise and spread of antibiotic resistant bacteria is posing a serious threat to the global health; antibiotic drugs are rendered ineffective and common infectious diseases become harder or impossible to treat. The beta-lactamase enzymes, with their ability to hydrolyze the beta-lactam antibiotics, are a major cause of resistant bacteria. The OXA-beta-lactamase enzymes are one of the most alarming ...
  • An Insight into the Aliivibrio genus. A comparative study on relationships and traits of species within the genus Aliivibrio 

    Klemetsen, Terje (Master thesis; Mastergradsoppgave, 2016-05-18)
    Few studies have emphasized on the genus Aliivibrio as a whole and lags behind the better known Vibrio. Nevertheless, the Aliivibrio has for several decades been associated with species expressing bioluminescence like the Aliivibrio fischeri, but has also been linked to costly diseases in the fish farming industry such as Aliivibrio salmonicida. In an attempt to gain insight in the genus on a ...
  • Vertical Diversity-Oriented Synthesis with Dibenzylideneacetones. Multivariate Optimization and Diversity Exploration. 

    Buhire, Phenias (Master thesis; Mastergradsoppgave, 2015-05-18)
    DOS was planned from dibenzylideneacetone to generate compound library with structural diversity, which can undergo further transformations. In the presented work, dibenzylideneacetone was cyclized under Robinson Annulation reaction. The resulting cyclization product was optimized using Multivariate response surface method. Response surface analysis helped to determine both significant variables ...
  • On the Synthesis of Breitfussins. Toward the total synthesis of Breitfussin A and analogues 

    Guttormsen, Yngve (Master thesis; Mastergradsoppgave, 2014-05)
    The Breitfussins are a series of closely related heterocyclic compounds originated from the marine organism Thelia Breitfussi. The core is a 5(indol-3-yl)-2-(pyrrol-2-yl)oxazole, which has not been observed prior to its isolation in 2007. The divergence of the Breitfussins lies in the halogenation pattern and methoxy substitution. Breitfussin A is of synthetic interest because of its novel structural ...
  • MD simulations reveal how synthetic antimicrobial peptides interact with membrane models 

    Sarre, Birta Ravdna (Master thesis; Mastergradsoppgave, 2014-12-17)
    Since the discovery of antibiotics the extensive use in health care and agriculture has led to the development of resistant bacterial strains. Antimicrobial peptides (AMPs) exists in nature where they are believed to play an important role in the innate immune system in vertebrates. Due to their antibacterial properties and apparent ability to elicit very low bacterial resistance, researchers have ...
  • Target characterization and ligand design directed at deoxyuridine 5'-triphospate nucleotidohydrolase 

    Liikanen, Laura Elina (Master thesis; Mastergradsoppgave, 2014-07-01)
    dUTPase is an important enzyme in DNA metabolism. It can be thought of as a gate keeper for apoptosis and is therefore an attractive target when trying to kill malign cells which cause disease in the human body. dUTPase has been found to be an important drug target in diseases such as cancer and malaria, to mention two. Due to problems with drug resistance in existing treatments, the search for new ...
  • Biophysical characterization of the DYRK family. Studies on the kinases DYRK1A and DYRK1B 

    Alexeeva, Marina (Master thesis; Mastergradsoppgave, 2013-11-13)
    The dual-specificity tyrosine phosphorylation-regulated kinase family (DYRKs) has recently emerged as new therapeutic targets for different kinds of cancer and neurodegenerative diseases. In the latest studies it was shown that DYRK1B plays a key role in cancer cell survival, and its inhibition induces apoptosis of cancer cells. This thesis is about the biophysical characterization of DYRK1B and ...
  • Identification, cloning and expressions of proteases from a cold adapted organism Aliivibrio salmonicida 

    Ather, Arjumand (Master thesis; Mastergradsoppgave, 2009-07-27)
    The work presented in this thesis provides an overview of molecular and structural biology projects and their related problems. The problems arises during these projects are common for most of the target proteins, with varying intensity of severity. The realization and identification of these problems and selection of their correct, best possible solution is an imperative step that might lead to ...
  • Reductions of barbituric acid based compounds 

    Kristoffersen, Stian (Master thesis; Mastergradsoppgave, 2013-05-15)
    Reductions of chalconoids with different para- substituents on the phenyl ring have been investigated in order to screen for kinase inhibitors with improved properties.
  • Synthesis of β-substituted β-aminoboronates 

    Thomassen, Ivar Kristian (Master thesis; Mastergradsoppgave, 2013-05)
    Recent work at the University of Tromsø has uncovered new α-substituted α- and β-aminoboron containing peptidomimetics that shows antimicrobial, antifungal and antitubercular activity in addition to kinase inhibition and promotion. As a continuation of this work a new approach for the synthesis of β-substituted β-aminoboronates has been developed. The approach involves the non-stereospecific ...

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