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dc.contributor.authorThomassen, Ivar K.
dc.contributor.authorRasmussen, Daniel
dc.contributor.authorEinrem, Rune F.
dc.contributor.authorGhosh, Abhik
dc.date.accessioned2022-01-07T14:30:22Z
dc.date.available2022-01-07T14:30:22Z
dc.date.issued2021-06-15
dc.description.abstractThe synthesis and purification of water-soluble porphyrin-type compounds for photodynamic therapy and other medical applications is often a tedious exercise. Here, we have investigated the simple stratagem of adding a water-soluble axial ligand to the standard protocol for iridium insertion into simple meso-triarylcorroles. Early results showed that six-coordinate Ir[TpXPC](dna)2 derivatives, in which TpXPC = tris(para-X-phenyl)corrole (X = CF3, CN, H, and OMe) and dna = dinicotinic acid, are highly water-soluble. In the end, however, all axially nitrogen-ligated complexes proved unstable with respect to chromatographic purification and storage. Five-coordinate water-soluble phosphine adducts, fortunately, proved a great improvement. From the point of view of ease of purification and storage, the best products proved to be Ir[TpXPC](L), where X = CF3 and OMe and L = tris(2-carboxyethyl)phosphine (tcep) and trisodium tris(3-sulfonatophenyl)phosphine (tppts); carefully optimized synthetic protocols are presented for these four compounds.en_US
dc.identifier.citationThomassen, I.K., Rasmussen, D. Einrem, R.F. & Ghosh, A. (2021). Simple, Axial Ligand-Mediated Route to Water-Soluble Iridium Corroles. <i>ACS Omega, 6</i>(25), 16683-16687.en_US
dc.identifier.cristinIDFRIDAID 1943977
dc.identifier.doi10.1021/acsomega.1c02399
dc.identifier.issn2470-1343
dc.identifier.urihttps://hdl.handle.net/10037/23641
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofEinrem, R.F. (2023). New Building Blocks for Cancer Phototherapeutics: 5d Metallocorroles. (Doctoral thesis). <a href=https://hdl.handle.net/10037/28538>https://hdl.handle.net/10037/28538</a>.
dc.relation.journalACS Omega
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/NANO21/ 262229/Norway/Metallocorroles for photodynamic therapy and bioimaging//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleSimple, Axial Ligand-Mediated Route to Water-Soluble Iridium Corrolesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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