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dc.contributor.authorIsaksson, Johan
dc.contributor.authorRylandsholm, Fredrik G.
dc.contributor.authorBouř, Petr
dc.contributor.authorSvendsen, John Sigurd Mjøen
dc.contributor.authorBrichtová, Eva
dc.contributor.authorChoi, Sng Un
dc.contributor.authorLee, Sang‑Ho
dc.contributor.authorJung, Young-Sik
dc.contributor.authorNo, Zae Sung
dc.contributor.authorAasen, Arne Jørgen
dc.contributor.authorDekebo, Aman
dc.contributor.authorDinku, Worku
dc.date.accessioned2022-01-17T08:49:27Z
dc.date.available2022-01-17T08:49:27Z
dc.date.issued2020-03-17
dc.description.abstractMyrrh, a resin derived from the damaged bark of Commiphora genus, has traditionally been used for treatment of various human diseases, such as amenorrhea, ache, tumors, fever, and stomach pains. In spite of this widespread use of the myrrh in Ethiopia, the pharmacological activity and chemical composition have not been studied in detail. A new tricyclic triterpene acid (3S,4S,14S,7E,17E,21Z)-3,30-dihydroxypodioda-7,17,21-trien-4-carboxylic acid (commafric A) has been isolated from a crude methanolic extract of Commiphora africana (A. Rich.) Engl. resin along with the known pentacyclic triterpene α-amyrin. The structure of commafric A was characterized using diferent spectroscopic techniques such as 1D and 2D NMR, IR, and VCD combined with computations. The anti-proliferative activity of both isolated compounds was evaluated using SRB based colorimetric cellular assay against four human cancer cell lines. Etoposide was used as a positive control. Commafric A showed signifcant anti-proliferative efects against non-small cell lung cancer (A549) with IC<sub>50</sub> values of 4.52 μg/ml. The pentacyclic triterpene α-amyrin showed a weak antiproliferative activity against A2780 (ovarian cancer), MIA-PaCa-2 (pancreatic cancer), and SNU638 (stomach cancer) cell lines tested with IC50 values ranging 9.28 to 28.22 μg/ml. Commafric A possessed anti-proliferative activity against non-small cell lung cancer (A549), which suggests that commafric A has potential to be further optimized being a lead compound in the search for new drugs against cancer diseases.en_US
dc.identifier.citationDinku, Isaksson, Rylandsholm, Bouř, Svendsen. Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines. Applied Biological Chemistry. 2020;63(1):16-27en_US
dc.identifier.cristinIDFRIDAID 1889961
dc.identifier.doi10.1186/s13765-020-00499-w
dc.identifier.issn2468-0834
dc.identifier.issn2468-0842
dc.identifier.urihttps://hdl.handle.net/10037/23695
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.ispartofRylandsholm, F.G. (2024). Structural characterisation and drug-lipid interaction by NMR spectroscopy. (Doctoral thesis). <a href=https://hdl.handle.net/10037/33752>https://hdl.handle.net/10037/33752</a>
dc.relation.journalApplied Biological Chemistry
dc.relation.projectIDinfo:eu-repo/grantAgreement/RCN/BIOTEK2021/269425/Norway/DL: Digital discovery of antimicrobial molecules from marine Arctic resources with reduced risk of triggering resistance//en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2020 The Author(s)en_US
dc.titleAnti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell linesen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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