dc.contributor.author | Gundappa, Manu Kumar | |
dc.contributor.author | To, Thu-Hien | |
dc.contributor.author | Grønvold, Lars | |
dc.contributor.author | Martin, Samuel A. M. | |
dc.contributor.author | Lien, Sigbjørn | |
dc.contributor.author | Geist, Jürgen | |
dc.contributor.author | Hazlerigg, David | |
dc.contributor.author | Sandve, Simen Rød | |
dc.contributor.author | Macqueen, Daniel J. | |
dc.date.accessioned | 2022-02-04T12:07:15Z | |
dc.date.available | 2022-02-04T12:07:15Z | |
dc.date.issued | 2021-10-28 | |
dc.description.abstract | The long-term evolutionary impacts of whole-genome duplication (WGD) are strongly influenced by the ensuing
rediploidization process. Following autopolyploidization, rediploidization involves a transition from tetraploid to diploid
meiotic pairing, allowing duplicated genes (ohnologs) to diverge genetically and functionally. Our understanding of
autopolyploid rediploidization has been informed by a WGD event ancestral to salmonid fishes, where large genomic
regions are characterized by temporally delayed rediploidization, allowing lineage-specific ohnolog sequence divergence
in the major salmonid clades. Here, we investigate the long-term outcomes of autopolyploid rediploidization at genomewide resolution, exploiting a recent “explosion” of salmonid genome assemblies, including a new genome sequence for
the huchen (Hucho hucho). We developed a genome alignment approach to capture duplicated regions across multiple
species, allowing us to create 121,864 phylogenetic trees describing genome-wide ohnolog divergence across salmonid
evolution. Using molecular clock analysis, we show that 61% of the ancestral salmonid genome experienced an initial
“wave” of rediploidization in the late Cretaceous (85–106 Ma). This was followed by a period of relative genomic stasis
lasting 17–39 My, where much of the genome remained tetraploid. A second rediploidization wave began in the early
Eocene and proceeded alongside species diversification, generating predictable patterns of lineage-specific ohnolog
divergence, scaling in complexity with the number of speciation events. Using gene set enrichment, gene expression,
and codon-based selection analyses, we provide insights into potential functional outcomes of delayed rediploidization.
This study enhances our understanding of delayed autopolyploid rediploidization and has broad implications for future
studies of WGD events | en_US |
dc.identifier.citation | Gundappa, To, Grønvold, Martin, Lien, Geist, Hazlerigg, Sandve, Macqueen. Genome-Wide Reconstruction of Rediploidization Following Autopolyploidization across One Hundred Million Years of Salmonid Evolution. Molecular Biology and Evolution (MBE). 2021 | en_US |
dc.identifier.cristinID | FRIDAID 1974753 | |
dc.identifier.doi | 10.1093/molbev/msab310 | |
dc.identifier.issn | 0737-4038 | |
dc.identifier.issn | 1537-1719 | |
dc.identifier.uri | https://hdl.handle.net/10037/23924 | |
dc.language.iso | eng | en_US |
dc.relation.journal | Molecular Biology and Evolution (MBE) | |
dc.relation.projectID | info:eu-repo/grantAgreement/RCN/FRIMEDBIO/241016/Norway/Light & Salt - Thyroid hormone deiodinase paralogues & the evolution of complex life-history strategy in salmonids// | en_US |
dc.relation.projectID | info:eu-repo/grantAgreement/RCN/FRIMEDBIO/275310/Norway/TRANSPOSE: Transposable elements as agents of genome evolution and adaptation following a recent whole genome duplication// | en_US |
dc.relation.projectID | info:eu-repo/grantAgreement/RCN/FRIMEDBIO/274669/Norway/The role of whole genome duplication in vertebrate adaptation// | en_US |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2021 The Author(s) | en_US |
dc.title | Genome-Wide Reconstruction of Rediploidization Following Autopolyploidization across One Hundred Million Years of Salmonid Evolution | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |