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dc.contributor.authorvan Rosmalen, Laura
dc.contributor.authorvan Dalum, Mattis Jayme
dc.contributor.authorAppenroth, Daniel
dc.contributor.authorRoodenrijs, Renzo T. M.
dc.contributor.authorde Wit, Lauren
dc.contributor.authorHazlerigg, David Grey
dc.contributor.authorHut, Roelof A.
dc.date.accessioned2022-03-01T08:40:00Z
dc.date.available2022-03-01T08:40:00Z
dc.date.issued2021-04-29
dc.description.abstractGlobal warming is predicted to have major effects on the annual time windows during which species may successfully reproduce. At the organismal level, climatic shifts engage with the control mechanism for reproductive seasonality. In mammals, laboratory studies on neuroendocrine mechanism emphasize photoperiod as a predictive cue, but this is based on a restricted group of species. In contrast, field-oriented comparative analyses demonstrate that proximate bioenergetic effects on the reproductive axis are a major determinant of seasonal reproductive timing. The interaction between proximate energetic and predictive photoperiodic cues is neglected. Here, we focused on photoperiodic modulation of postnatal reproductive development in common voles (Microtus arvalis), a herbivorous species in which a plastic timing of breeding is well documented. We demonstrate that temperature-dependent modulation of photoperiodic responses manifest in the thyrotrophin-sensitive tanycytes of the mediobasal hypothalamus. Here, the photoperiod-dependent expression of type 2 deiodinase expression, associated with the summer phenotype was enhanced by 21°C, whereas the photoperiod-dependent expression of type 3 deiodinase expression, associated with the winter phenotype, was enhanced by 10°C in spring voles. Increased levels of testosterone were found at 21°C, whereas somatic and gonadal growth were oppositely affected by temperature. The magnitude of these temperature effects was similar in voles photoperiodical programmed for accelerated maturation (ie, born early in the breeding season) and in voles photoperiodical programmed for delayed maturation (ie, born late in the breeding season). The melatonin-sensitive pars tuberalis was relatively insensitive to temperature. These data define a mechanistic hierarchy for the integration of predictive temporal cues and proximate thermo-energetic effects in mammalian reproduction.en_US
dc.identifier.citationvan Rosmalen, van Dalum, Appenroth, Roodenrijs, de Wit, Hazlerigg, Hut. Mechanisms of temperature modulation in mammalian seasonal timing. The FASEB Journal. 2021;35(5)en_US
dc.identifier.cristinIDFRIDAID 2004818
dc.identifier.doi10.1096/fj.202100162R
dc.identifier.issn0892-6638
dc.identifier.issn1530-6860
dc.identifier.urihttps://hdl.handle.net/10037/24194
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.ispartofvan Dalum, M.J. (2022). Evolution of seasonal adaptations in voles - a physiological and genetic approach. (Doctoral thesis). <a href=https://hdl.handle.net/10037/24919>https://hdl.handle.net/10037/24919</a>.
dc.relation.journalThe FASEB Journal
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleMechanisms of temperature modulation in mammalian seasonal timingen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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