Show simple item record

dc.contributor.authorPalica, Katarzyna
dc.contributor.authorVorácová, Manuela
dc.contributor.authorSkagseth, Susann
dc.contributor.authorAndersson Rasmussen, Anna
dc.contributor.authorAllander, Lisa
dc.contributor.authorHubert, Madlen
dc.contributor.authorSandegren, Linus
dc.contributor.authorLeiros, Hanna-Kirsti S.
dc.contributor.authorAndersson, Hanna
dc.contributor.authorErdélyi, Máté
dc.date.accessioned2022-03-07T12:02:16Z
dc.date.available2022-03-07T12:02:16Z
dc.date.issued2022-01-25
dc.description.abstractBeing the second leading cause of death and the leading cause of disability-adjusted life years worldwide, infectious diseases remain-contrary to earlier predictions-a major consideration for the public health of the 21st century. Resistance development of microbes to antimicrobial drugs constitutes a large part of this devastating problem. The most widely spread mechanism of bacterial resistance operates through the degradation of existing β-lactam antibiotics. Inhibition of metallo-βlactamases is expected to allow the continued use of existing antibiotics, whose applicability is becoming ever more limited. Herein, we describe the synthesis, the metallo-β-lactamase inhibition activity, the cytotoxicity studies, and the NMR spectroscopic determination of the protein binding site of phosphonamidate monoesters. The expression of single- and doublelabeled NDM-1 and its backbone NMR assignment are also disclosed, providing helpful information for future development of NDM-1 inhibitors. We show phosphonamidates to have the potential to become a new generation of antibiotic therapeutics to combat metallo-β-lactamase-resistant bacteria.en_US
dc.identifier.citationPalica, Vorácová, Skagseth, Andersson Rasmussen, Allander, Hubert, Sandegren, Leiros, Andersson, Erdélyi. Metallo-β-Lactamase Inhibitor Phosphonamidate Monoesters. ACS Omega. 2021;7:4550-4562en_US
dc.identifier.cristinIDFRIDAID 2003067
dc.identifier.doi10.1021/acsomega.1c06527
dc.identifier.issn2470-1343
dc.identifier.urihttps://hdl.handle.net/10037/24299
dc.language.isoengen_US
dc.publisherAmerican chemical societyen_US
dc.relation.journalACS Omega
dc.relation.urihttps://doi.org/10.1021/acsomega.1c06527
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2021 The Author(s)en_US
dc.titleMetallo-β-Lactamase Inhibitor Phosphonamidate Monoestersen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record