ub.xmlui.mirage2.page-structure.muninLogoub.xmlui.mirage2.page-structure.openResearchArchiveLogo
    • EnglishEnglish
    • norsknorsk
  • Velg spraaknorsk 
    • EnglishEnglish
    • norsknorsk
  • Administrasjon/UB
Vis innførsel 
  •   Hjem
  • Fakultet for naturvitenskap og teknologi
  • Institutt for fysikk og teknologi
  • Artikler, rapporter og annet (fysikk og teknologi)
  • Vis innførsel
  •   Hjem
  • Fakultet for naturvitenskap og teknologi
  • Institutt for fysikk og teknologi
  • Artikler, rapporter og annet (fysikk og teknologi)
  • Vis innførsel
JavaScript is disabled for your browser. Some features of this site may not work without it.

Imaging the Effects of Whole-Body Vibration on the Progression of Hepatic Steatosis by Quantitative Ultrasound Based on Backscatter Envelope Statistics

Permanent lenke
https://hdl.handle.net/10037/26724
DOI
https://doi.org/10.3390/pharmaceutics14040741
Thumbnail
Åpne
article.pdf (3.568Mb)
Publisert versjon (PDF)
Dato
2022-03-29
Type
Journal article
Tidsskriftartikkel
Peer reviewed

Forfatter
Fang, Jui; Lai, Ming-Wei; Cheng, Hao-Tsai; Cristea, Anca; Zhou, Zhuhuang; Tsui, Po-Hsiang
Sammendrag
Hepatic steatosis causes nonalcoholic fatty liver disease. Whole-body vibration (WBV) has been recommended to allow patients who have difficulty engaging in exercise to improve the grade of hepatic steatosis. This study proposed using ultrasound parametric imaging of the homodyned K (HK) distribution to evaluate the effectiveness of WBV treatments in alleviating hepatic steatosis. Sixty mice were assigned to control (n = 6), sedentary (n = 18), WBV (n = 18), and exercise (swimming) (n = 18) groups. Mice were fed a high-fat diet to induce hepatic steatosis and underwent the intervention for 4, 8, and 16 weeks. Ultrasound scanning was performed in vivo on each mouse after the interventions for ultrasound HK imaging using the parameter μ (the scatterer clustering parameter). Histopathological examinations and the intraperitoneal glucose tolerance test were carried out for comparisons with ultrasound findings. At the 16th week, WBV and exercise groups demonstrated lower body weights, glucose concentrations, histopathological scores (steatosis and steatohepatitis), and μ parameters than the control group (p < 0.05). The steatosis grade was significantly lower in the WBV group (mild) than in the exercise group (moderate) (p < 0.05), corresponding to a reduction in the μ parameter. A further analysis revealed that the correlation between the steatosis grade and the μ parameter was 0.84 (p < 0.05). From this animal study we conclude that WBV may be more effective than exercise in reducing the progression of hepatic steatosis, and ultrasound HK parametric imaging is an appropriate method for evaluating WBV’s effect on hepatic steatosis.
Forlag
MDPI
Sitering
Fang, Lai, Cheng, Cristea, Zhou, Tsui. Imaging the Effects of Whole-Body Vibration on the Progression of Hepatic Steatosis by Quantitative Ultrasound Based on Backscatter Envelope Statistics. Pharmaceutics. 2022;14(4)
Metadata
Vis full innførsel
Samlinger
  • Artikler, rapporter og annet (fysikk og teknologi) [1057]
Copyright 2022 The Author(s)

Bla

Bla i hele MuninEnheter og samlingerForfatterlisteTittelDatoBla i denne samlingenForfatterlisteTittelDato
Logg inn

Statistikk

Antall visninger
UiT

Munin bygger på DSpace

UiT Norges Arktiske Universitet
Universitetsbiblioteket
uit.no/ub - munin@ub.uit.no

Tilgjengelighetserklæring