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dc.contributor.authorLean, Fabian Z.X.
dc.contributor.authorCox, Ruth
dc.contributor.authorMadslien, Knut
dc.contributor.authorSpiro, Simon
dc.contributor.authorNymo, Ingebjørg Helena
dc.contributor.authorBröjer, Caroline
dc.contributor.authorNeimanis, Aleksija
dc.contributor.authorLawson, Becki
dc.contributor.authorHolmes, Paul
dc.contributor.authorMan, Catherine
dc.contributor.authorFolkow, Lars
dc.contributor.authorGough, Julie
dc.contributor.authorAckroyd, Stuart
dc.contributor.authorEvans, Liam
dc.contributor.authorWrigglesworth, Ethan
dc.contributor.authorGrimholt, Unni
dc.contributor.authorMcElhinney, Lorraine
dc.contributor.authorBrookes, Sharon M.
dc.contributor.authorDelahay, Richard J.
dc.contributor.authorNúñez, Alejandro
dc.date.accessioned2023-08-15T09:16:19Z
dc.date.available2023-08-15T09:16:19Z
dc.date.issued2023-01-25
dc.description.abstractNatural cases of zooanthroponotic transmission of SARS-CoV-2 to animals have been reported during the COVID-19 pandemic, including to free-ranging white-tailed deer (<i>Odocoileus virginianus</i>) in North America and farmed American mink (<i>Neovison vison</i>) on multiple continents. To understand the potential for angiotensin-converting enzyme 2 (ACE2)-mediated viral tropism we characterised the distribution of ACE2 receptors in the respiratory and intestinal tissues of a selection of wild and semi-domesticated mammals including artiodactyls (cervids, bovids, camelids, suids and hippopotamus), mustelid and phocid species using immunohistochemistry. Expression of the ACE2 receptor was detected in the bronchial or bronchiolar epithelium of several European and Asiatic deer species, Bactrian camel (<i>Camelus bactrianus</i>), European badger (<i>Meles meles</i>), stoat (<i>Mustela erminea</i>), hippopotamus (<i>Hippopotamus amphibious</i>), harbor seal (<i>Phoca vitulina</i>), and hooded seal (<i>Cystophora cristata</i>). Further receptor mapping in the nasal turbinates and trachea revealed sparse ACE2 receptor expression in the mucosal epithelial cells and occasional occurrence in the submucosal glandular epithelium of Western roe deer (<i>Capreolus capreolus</i>), moose (<i>Alces alces alces</i>), and alpaca (<i>Vicunga pacos</i>). Only the European badger and stoat expressed high levels of ACE2 receptor in the nasal mucosal epithelium, which could suggest high susceptibility to ACE2-mediated respiratory infection. Expression of ACE2 receptor in the intestinal cells was ubiquitous across multiple taxa examined. Our results demonstrate the potential for ACE2-mediated viral infection in a selection of wild mammals and highlight the intra-taxon variability of ACE2 receptor expression, which might influence host susceptibility and infection.en_US
dc.description.sponsorshipEUen_US
dc.identifier.citationLean, Cox, Madslien, Spiro, Nymo, Bröjer, Neimanis, Lawson, Holmes, Man, Folkow, Gough, Ackroyd, Evans, Wrigglesworth, Grimholt, McElhinney, Brookes, Delahay, Núñez. Tissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocids. One Health. 2023;16:1-9en_US
dc.identifier.cristinIDFRIDAID 2133017
dc.identifier.doi10.1016/j.onehlt.2023.100492
dc.identifier.issn2352-7714
dc.identifier.urihttps://hdl.handle.net/10037/29945
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalOne Health
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/773830/EU/Promoting One Health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards/OHEJP/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleTissue distribution of angiotensin-converting enzyme 2 (ACE2) receptor in wild animals with a focus on artiodactyls, mustelids and phocidsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)