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dc.contributor.authorvan Dalum, Mattis Jayme
dc.contributor.authorvan Rosmalen, Laura
dc.contributor.authorAppenroth, Daniel
dc.contributor.authorCazarez Marquez, Fernando
dc.contributor.authorRoodenrijs, Renzo T. M.
dc.contributor.authorde Wit, Lauren
dc.contributor.authorHut, Roelof A.
dc.contributor.authorHazlerigg, David Grey
dc.date.accessioned2023-10-13T13:03:18Z
dc.date.available2023-10-13T13:03:18Z
dc.date.issued2023-08-11
dc.description.abstractSeasonal mammals register photoperiodic changes through the photoneuroendocrine system enabling them to time seasonal changes in growth, metabolism, and reproduction. To a varying extent, proximate environmental factors like ambient temperature (Ta) modulate timing of seasonal changes in physiology, conferring adaptive flexibility. While the molecular photoneuroendocrine pathway governing the seasonal responses is well defined, the mechanistic integration of nonphotoperiodic modulatory cues is poorly understood. Here, we explored the interaction between Ta and photoperiod in tundra voles, Microtus oeconomus, a boreal species in which the main impact of photoperiod is on postnatal somatic growth. We demonstrate that postweaning growth potential depends on both gestational and postweaning patterns of photoperiodic exposure, with the highest growth potential seen in voles experiencing short (8 h) gestational and long (16 h) postweaning photoperiods—corresponding to a spring growth program. Modulation by Ta was asymmetric: low Ta (10 °C) enhanced the growth potential of voles gestated on short photoperiods independent of postweaning photoperiod exposure, whereas in voles gestated on long photoperiods, showing a lower autumn-programmed growth potential, the effect of Ta was highly dependent on postweaning photoperiod. Analysis of the primary molecular elements involved in the expression of a neuroendocrine response to photoperiod, thyrotropin beta subunit (tshβ) in the pars tuberalis, somatostatin (srif) in the arcuate nucleus, and type 2/3 deiodinase (dio2/dio3) in the mediobasal hypothalamus identified dio2 as the most Ta-sensitive gene across the study, showing increased expression at higher Ta, while higher Ta reduced somatostatin expression. Contrastingly dio3 and tshβ were largely insensitive to Ta. Overall, these observations reveal a complex interplay between Ta and photoperiodic control of postnatal growth in M. oeconomus, and suggest that integration of Ta into the control of growth occurs downstream of the primary photoperiodic response cascade revealing potential adaptivity of small herbivores facing rising temperatures at high latitudes.en_US
dc.identifier.citationvan Dalum, van Rosmalen, Appenroth, Cazarez Marquez, Roodenrijs, de Wit, Hut, Hazlerigg. Ambient Temperature Effects on the Spring and Autumn Somatic Growth Trajectory Show Plasticity in the Photoneuroendocrine Response Pathway in the Tundra Vole. Journal of Biological Rhythms. 2023en_US
dc.identifier.cristinIDFRIDAID 2183372
dc.identifier.doi10.1177/07487304231190156
dc.identifier.issn0748-7304
dc.identifier.issn1552-4531
dc.identifier.urihttps://hdl.handle.net/10037/31553
dc.language.isoengen_US
dc.publisherSAGE Publicationsen_US
dc.relation.journalJournal of Biological Rhythms
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleAmbient Temperature Effects on the Spring and Autumn Somatic Growth Trajectory Show Plasticity in the Photoneuroendocrine Response Pathway in the Tundra Voleen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)