Institutt for klinisk medisin: Nye registreringer
Viser treff 301-320 av 1804
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Hand grip strength and risk of incident venous thromboembolism: The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-04)<p><b> Background</b> Hand grip strength (HGS), a common proxy of whole-body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). <p><b> Objectives</b> We aimed to investigate the association between HGS and risk of incident VTE in a population-based ... -
Real-world comparison of the effects of etanercept and adalimumab on well-being in non-systemic juvenile idiopathic arthritis: a propensity score matched cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-14)Background: Etanercept (ETN) and adalimumab (ADA) are considered equally efective biologicals in the treat‑ ment of arthritis in juvenile idiopathic arthritis (JIA) but no studies have compared their impact on patient-reported well-being. The objective of this study was to determine whether ETN and ADA have a diferential efect on patientreported well-being in non-systemic JIA using real-world ... -
Treatment and survival of patients with pancreatic ductal adenocarcinoma: 15-year national cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-08)Background - Improvement in survival from pancreatic ductal adenocarcinoma (PDAC) has been reported in trial settings but is less explored in unselected cohorts. The aim of this study was to assess trends in provision of treatments and survival in Norway over a 15-year period following the implementation of hepato-pancreato-biliary (HPB) multidisciplinary teams, centralization of surgery, and ... -
Ten-year tenure as a physician CEO at a Nordic university hospital: Five lessons learnt
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-21)Background - I was a 42-year-old neurosurgeon with experience as department head when I took chair as chief executive officer (CEO) at the University Hospital of North Norway to lead a comprehensive organisational and financial restructuring. This article aims to develop lessons learnt during my 10-year tenure.<p> <p>Methods - I restructured the organisation and hired a new executive team. We ... -
Kjønnsstratifiserte analyser i norske behandlingsstudier: en systematisk kartleggingsoversikt
(Research report; Forskningsrapport, 2022)Biologisk kjønn har betydning for kliniske utfall, og kunnskap om kjønnsforskjeller i behandlingsutfall kan bidra til sikrere og mer tilpasset behandling for pasienter. Hensikten med denne kartleggingsoversikten var å undersøke bruken av kjønnsstratifiserte analyser i studier på effekt av behandling i en norsk sammenheng.<p> <p>Vi utførte en kartleggingsoversikt. Det er en type kunnskapsoppsummering ... -
Nasjonale og regionale melde- og varselordninger for uønskede hendelser i pasientbehandlingen: systematisk oversikt
(Research report; Forskningsrapport, 2022)Alle virksomheter som yter helse- og omsorgstjenester skal arbeide systematisk for å redusere risiko for pasientskade som følge av tjenesteytelsen eller mangel på ytelse. Likevel oppstår uønskede hendelser av varierende alvorlighetsgrad. Anslagsvis rammer uønskede hendelser én av ti pasienter i norske sykehus. Norske virksomheter som yter helse- og omsorgstjenester plikter å varsle om alvorlige ... -
Utvalgt forskning om melde- og varselordninger i helse- og omsorgstje-nesten: forenklet metodevurdering – kartlegging
(Research report; Forskningsrapport, 2022-10)En nylig utført systematisk oversikt viste at det ikke finnes forskning som har undersøkt effekten av nasjonale og regionale, generelle melde- og varselordninger på alvorlige hendelser i helse- og omsorgstjenesten. Derfor var det hensiktsmessig å undersøke forskning som har sett på tilgrensende problemstillinger.<p> <p>Formålet med dette arbeidet var å kartlegge studier om mulige sammenhenger ... -
Sex differences in arterial hypertension
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)There is strong evidence that sex chromosomes and sex hormones influence blood pressure (BP) regulation, distribution of cardiovascular (CV) risk factors and co-morbidities differentially in females and males with essential arterial hypertension. The risk for CV disease increases at a lower BP level in females than in males, suggesting that sex-specific thresholds for diagnosis of hypertension may ... -
Discovering the structure and organization of a free Cantonese emotion-label word association graph to understand mental lexicons of emotions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-15)Emotions are not necessarily universal across different languages and cultures. Mental lexicons of emotions depend strongly on contextual factors, such as language and culture. The Chinese language has unique linguistic properties that are different from other languages. As a main variant of Chinese, Cantonese has some emotional expressions that are only used by Cantonese speakers. Previous work on ... -
Prediction of long-term remission in patients following discontinuation of anti-TNF therapy in ulcerative colitis: a 10 year follow up study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-16)Background - The long-term outcomes of Ulcerative colitis (UC) after discontinuation of biological therapy are largely unknown. There is also a lack of accurate and validated markers that can predict outcome after withdrawal accurately. The aims of this study were to describe the long-term outcomes in UC patients following cessation of anti-TNF therapy and explore potential biomarkers as an approach ... -
Pharmacodynamic mechanisms behind a refractory state in inflammatory bowel disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-17)Background and aims - Biological therapy for inflammatory bowel disease is efficient in many cases but not all. The underlying molecular mechanisms behind non-response to biological therapy in inflammatory bowel disease are poorly described. Therefore, we aimed to characterize the mucosal cytokine transcript profile in non-immunogenic, non-responder patients with adequate trough level.<p> <p>Material ... -
Outcomes and predictors of functioning, mental health, and health-related quality of life in adults born with very low birth weight: a prospective longitudinal cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-03)Background - Very low birth weight (VLBW: ≤1500 g) is associated with multiple short and long-term complications. This study aimed to examine outcomes and predictors of functioning, mental health, and health-related quality of life in adults born with VLBW.<p> <p>Methods - In this prospective longitudinal cohort study, 67 VLBW and 102 control participants were assessed using the Adult Self-Report ... -
Testing for association with rare variants in the coding and non-coding genome: RAVA-FIRST, a new approach based on CADD deleteriousness score
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-16)Rare variant association tests (RVAT) have been developed to study the contribution of rare variants widely accessible through high-throughput sequencing technologies. RVAT require to aggregate rare variants in testing units and to filter variants to retain only the most likely causal ones. In the exome, genes are natural testing units and variants are usually filtered based on their functional ... -
Extracurricular work experience and its association with training and confidence in emergency medicine procedures among medical students: a cross-sectional study from a Norwegian medical school
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-27)<p><b> Objective </b> Proficiency in basic emergency procedures is important for junior doctors, but the amount of practical exposure may vary. We studied the association between students’ extracurricular healthcare-related (ECHR) work experience and self-reported practical training and confidence in selected emergency medicine procedures. <p><b> Study design</b> Cross-sectional ... -
Parents’ perspectives on preparing for parenthood: a qualitative study on Greenland’s universal parenting programme MANU 0–1 year
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-20)<p><b> Background</b> The transition to parenthood has received increasing attention in research, partly due to evidence pointing out the crucial developmental period of a child’s first thousand days. Parenting programmes aim to prepare and support families in their transition and distress. For a programme to be implemented successfully it is important to consider parents’ needs and resources. ... -
Genetically predicted cortisol levels and risk of venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-19)Introduction - In observational studies, venous thromboembolism (VTE) has been associated with Cushing’s syndrome and with persistent mental stress, two conditions associated with higher cortisol levels. However, it remains unknown whether high cortisol levels within the usual range are causally associated with VTE risk. We aimed to assess the association between plasma cortisol levels and VTE risk ... -
The development of a tool to assess medical students’ non-technical skills–The Norwegian medical students’ non-technical skills (NorMS-NTS)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)Purpose - New physicians need to master non-technical skills (NTS), as high levels of NTS have been shown to increase patient safety. It has also been shown that NTS can be improved through training. This study aimed to establish the necessary NTS for Norwegian medical students to create a tool for formative and summative assessments.<p> <p>Methods - Focus group interviews were conducted with ... -
Associations of serum 25-hydroxyvitamin D and subjective sleep measures in an arctic population: Insights from the population-based Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-06)Objective - To investigate the relation between serum 25-hydroxyvitamin D (s-25(OH)D) and subjective sleep measures in an Arctic population (69°N).<p> <p>Methods - Cross-sectional data was collected from 21,083 individuals (aged ≥40 years) participating in the population based Tromsø Study: Tromsø7 (2015–2016). The present study included 20,438 participants, after having excluded respondents ... -
The precarity of patient participation - a qualitative interview study of experiences from the acute stroke and rehabilitation journey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)Introduction: Active patient participation is an important factor in optimizing post-stroke recovery, yet it is often low, regardless of stroke severity. The reasons behind this trend are unclear.<p> <p>Purpose: To explore how people who have suffered a stroke, perceive the transition from independence to dependence and whether their role in post-stroke rehabilitation influences active ... -
Sex Differences in Age-Related Loss of Kidney Function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-30)Background - CKD is more prevalent in women, but more men receive kidney replacement therapy for kidney failure. This apparent contradiction is not well understood.<p> <p>Methods - We investigated sex differences in the loss of kidney function and whether any sex disparities could be explained by comorbidity or CKD risk factors. In the Renal Iohexol Clearance Survey (RENIS) in northern Europe, ...