Incoherent speech in schizophrenia has long been described as the mind making “leaps” of large distances between thoughts and ideas. Such a view seems intuitive, and for almost two decades, attempts to operationalize these conceptual “leaps” in spoken word meanings have used language-based embedding spaces. An embedding space represents meaning of words as numerical vectors where a greater proximity ...

Purpose By using data from the Norwegian Registry for Spine Surgery, we wanted to develop and validate prediction models for non-success in patients operated with anterior surgical techniques for cervical degenerative radiculopathy (CDR).<p> <p>Methods This is a multicentre longitudinal study of 2022 patients undergoing CDR surgery and followed for 12 months to fnd prognostic models for non-success ...

Hyperfiltration is a state of high glomerular filtration rate (GFR) observed in early diabetes that damages glomeruli, resulting in an iterative process of increasing filtration load on fewer and fewer remaining functional glomeruli. To delineate underlying cellular mechanisms of damage associated with hyperfiltration, transcriptional profiles of kidney biopsies from Pima Indians with type 2 ...

<p><b> Background</b> Hand grip strength (HGS), a common proxy of whole-body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). <p><b> Objectives</b> We aimed to investigate the association between HGS and risk of incident VTE in a population-based ...

Background - Improvement in survival from pancreatic ductal adenocarcinoma (PDAC) has been reported in trial settings but is less explored in unselected cohorts. The aim of this study was to assess trends in provision of treatments and survival in Norway over a 15-year period following the implementation of hepato-pancreato-biliary (HPB) multidisciplinary teams, centralization of surgery, and ...

Biologisk kjønn har betydning for kliniske utfall, og kunnskap om kjønnsforskjeller i behandlingsutfall kan bidra til sikrere og mer tilpasset behandling for pasienter. Hensikten med denne kartleggingsoversikten var å undersøke bruken av kjønnsstratifiserte analyser i studier på effekt av behandling i en norsk sammenheng.<p> <p>Vi utførte en kartleggingsoversikt. Det er en type kunnskapsoppsummering ...

En nylig utført systematisk oversikt viste at det ikke finnes forskning som har undersøkt effekten av nasjonale og regionale, generelle melde- og varselordninger på alvorlige hendelser i helse- og omsorgstjenesten. Derfor var det hensiktsmessig å undersøke forskning som har sett på tilgrensende problemstillinger.<p> <p>Formålet med dette arbeidet var å kartlegge studier om mulige sammenhenger ...

Emotions are not necessarily universal across different languages and cultures. Mental lexicons of emotions depend strongly on contextual factors, such as language and culture. The Chinese language has unique linguistic properties that are different from other languages. As a main variant of Chinese, Cantonese has some emotional expressions that are only used by Cantonese speakers. Previous work on ...

Background and aims - Biological therapy for inflammatory bowel disease is efficient in many cases but not all. The underlying molecular mechanisms behind non-response to biological therapy in inflammatory bowel disease are poorly described. Therefore, we aimed to characterize the mucosal cytokine transcript profile in non-immunogenic, non-responder patients with adequate trough level.<p> <p>Material ...

Rare variant association tests (RVAT) have been developed to study the contribution of rare variants widely accessible through high-throughput sequencing technologies. RVAT require to aggregate rare variants in testing units and to filter variants to retain only the most likely causal ones. In the exome, genes are natural testing units and variants are usually filtered based on their functional ...