Abstract Introduction: Diabetes mellitus is an increasingly public health concern, causing increased mortality, morbidity and healthcare costs globally. Global increase in overweight and obesity, high calorie diets, sedentary lifestyle, smoking habits and aging population are the main drivers for this epidemic. Social inequalities reveal systematic differences in health and disease. Social inequalities ...

Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. Here we report a comprehensive multi-element genome-wide association study of 57 essential and non-essential trace elements. We perform genome-wide association meta-analyses of ...

Background Russia has a higher cardiovascular disease (CVD) mortality rate compared to other European countries. This study aimed to investigate the awareness of hypertension, hypercholesterolemia, and diabetes mellitus among Russian adults with the objective presence of these conditions. Material and Methods We used cross-sectional data from a general population-based study of Russian adults ...

Abstract Introduction: Retinopathy is a retinal disorder characterized by microvascular complications due to ocular or systemic conditions. The non-invasive visualization of retinal blood vessels provides a way to study the early structural and pathological changes in the circulatory system. Hence retinopathies can be used to monitor risk factors for cardiovascular diseases. Several studies have ...

Background: Colorectal cancer (CRC) is one of the most common cancer types and a leading cause of cancer death worldwide. Norwegian women had the highest incidence rate in 2020 compared to women in other countries. Existing evidence suggests that the dietary inflammatory potential is associated with the risk of CRC and that the risk may vary by anatomical subsite. However, the findings are inconsistent ...

Background: Lipedema is an adipose tissue condition in females characterized by immobility, pain, and reduced quality of life (QoL). Recent publications indicate that ketogenic diets may induce symptom relief in women with lipedema. The aim of this study was to investigate the impact of a low-energy ketogenic diet on pain and QoL in women with lipedema, compared to a low-energy non-ketogenic ...

<p><i>Introduction</i> COVID-19 may have negatively impacted the mental health of front-line healthcare workers, including general practitioners (GPs). This study sought to assess the psychological impact (stress, burnout and self-efficacy) of the COVID-19 outbreak in French GPs. <p><i>Methods</i> We carried out a postal-based survey of all GPs who worked in the French region of Normandy (departments ...

Background - Childhood, adolescent and young-adult (AYA) cancer survivors often experience health problems due to late or long-term effects of their cancer or the treatment thereof. The general population gains health benefits from immersion in nature, and nature-based programmes seem to be an intervention that can promote health among childhood and AYA cancer survivors.<p> <p>Objective - To ...

Noncommunicable diseases are among the most significant health threats in our society, being cardiovascular diseases (CVD) the most prevalent. Because of the severity and prevalence of these illnesses, early detection and prevention are critical for reducing the worldwide health and economic burden. Though machine learning (ML) methods usually outperform conventional approaches in many domains, class ...

Background: Per- and polyfluoroalkyl substances (PFAS) comprise a large group of chemicals that are ubiquitous in the environment and include recognized persistent organic pollutants. The aim of this cross-sectional study was to investigate possible endocrine disrupting effects of different PFAS in adolescents. <p> <p>Methods: Serum concentrations of PFAS, thyroid, parathyroid and steroid hormones ...