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dc.contributor.authorHazlerigg, David Grey
dc.contributor.authorSimonneaux, Valérie
dc.contributor.authorDardente, Hugues
dc.date.accessioned2024-10-03T10:53:00Z
dc.date.available2024-10-03T10:53:00Z
dc.date.issued2024-08-12
dc.description.abstractIn mammals, seasonal opportunities and challenges are anticipated through programmed changes in physiology and behavior. Appropriate anticipatory timing depends on synchronization to the external solar year, achieved through the use of day length (photoperiod) as a synchronizing signal. In mammals, nocturnal production of melatonin by the pineal gland is the key hormonal mediator of photoperiodic change, exerting its effects via the hypothalamopituitary axis. In this review/perspective, we consider the key developments during the history of research into the seasonal synchronizer effect of melatonin, highlighting the role that the pars tuberalis–tanycyte module plays in this process. We go on to consider downstream pathways, which include discrete hypothalamic neuronal populations. Neurons that express the neuropeptides kisspeptin and (Arg)(Phe)–related peptide-3 (RFRP-3) govern seasonal reproductive function while neurons that express somatostatin may be involved in seasonal metabolic adaptations. Finally, we identify several outstanding questions, which need to be addressed to provide a much thorough understanding of the deep impact of melatonin upon seasonal synchronization.en_US
dc.identifier.citationHazlerigg, Simonneaux, Dardente. Melatonin and Seasonal Synchrony in Mammals. Journal of Pineal Research. 2024;76(5)en_US
dc.identifier.cristinIDFRIDAID 2289511
dc.identifier.doi10.1111/jpi.12996
dc.identifier.issn0742-3098
dc.identifier.issn1600-079X
dc.identifier.urihttps://hdl.handle.net/10037/35017
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalJournal of Pineal Research
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
dc.rightsAttribution-NonCommercial 4.0 International (CC BY-NC 4.0)en_US
dc.titleMelatonin and Seasonal Synchrony in Mammalsen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)