dc.contributor.author | Hazlerigg, David Grey | |
dc.contributor.author | Simonneaux, Valérie | |
dc.contributor.author | Dardente, Hugues | |
dc.date.accessioned | 2024-10-03T10:53:00Z | |
dc.date.available | 2024-10-03T10:53:00Z | |
dc.date.issued | 2024-08-12 | |
dc.description.abstract | In mammals, seasonal opportunities and challenges are anticipated through programmed changes in physiology and behavior. Appropriate anticipatory timing depends on synchronization to the external solar year, achieved through the use of day length (photoperiod) as a synchronizing signal. In mammals, nocturnal production of melatonin by the pineal gland is the key hormonal mediator of photoperiodic change, exerting its effects via the hypothalamopituitary axis. In this review/perspective, we consider the key developments during the history of research into the seasonal synchronizer effect of melatonin, highlighting the role that the pars tuberalis–tanycyte module plays in this process. We go on to consider downstream pathways, which include discrete hypothalamic neuronal populations. Neurons that express the neuropeptides kisspeptin and (Arg)(Phe)–related peptide-3 (RFRP-3) govern seasonal reproductive function while neurons that express somatostatin may be involved in seasonal metabolic adaptations. Finally, we identify several outstanding questions, which need to be addressed to provide a much thorough understanding of the deep impact of melatonin upon seasonal synchronization. | en_US |
dc.identifier.citation | Hazlerigg, Simonneaux, Dardente. Melatonin and Seasonal Synchrony in Mammals. Journal of Pineal Research. 2024;76(5) | en_US |
dc.identifier.cristinID | FRIDAID 2289511 | |
dc.identifier.doi | 10.1111/jpi.12996 | |
dc.identifier.issn | 0742-3098 | |
dc.identifier.issn | 1600-079X | |
dc.identifier.uri | https://hdl.handle.net/10037/35017 | |
dc.language.iso | eng | en_US |
dc.publisher | Wiley | en_US |
dc.relation.journal | Journal of Pineal Research | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2024 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0 | en_US |
dc.rights | Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) | en_US |
dc.title | Melatonin and Seasonal Synchrony in Mammals | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |