Blar i forfatter Det helsevitenskapelige fakultet "Dønnem, Tom"

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    • High number of kinome-mutations in non-small cell lung cancers associated with reduced immune response and poor relapse-free survival 

      Helland, Åslaug; Brustugun, Odd Terje; Nakken, Sigve; Halvorsen, Ann Rita; Dønnem, Tom; Bremnes, Roy M.; Busund, Lill-Tove; Sun, Jinchang; Lorenz, Susanne; Solberg, Steinar; Jørgensen, Lars Hilmar; Vodak, Daniel; Myklebost, Ola; Hovig, Eivind; Meza, Leonardo Zepeda (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-07)
      Lung cancer is the leading cause of cancer related death, and the past years’ improved insight into underlying molecular events has significantly improved outcome for specific subsets of patients. In particular, several new therapies that target protein kinases have been implemented, and many more are becoming available. We have investigated lung cancer specimens for somatic mutations in a targeted ...

    • High progesterone receptor expression in prostate cancer is associated with clinical failure 

      Grindstad, Thea; Andersen, Sigve; Al-Saad, Samer; Dønnem, Tom; Kiselev, Yury; Melbø-Jørgensen, Christian; Skjefstad, Kaja; Busund, Lill-Tove; Bremnes, Roy M.; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-27)
      Background Prostate cancer is a highly heterogeneous disease and one of the leading causes of mortality in developed countries. Specific prognostic and predictive markers for prostate cancer patients are still lacking. A causal relationship between androgens and the development of prostate cancer is generally considered biologically plausible, but androgens are not the sole effector in the ...

    • High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome 

      Stenvold, Helge; Dønnem, Tom; Andersen, Sigve; Al-Saad, Samer; Valkov, Andrey Yurjevich; Pedersen, Mona Irene; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • The impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer 

      Al-Saad, Samer; Richardsen, Elin; Kilvær, Thomas Karsten; Dønnem, Tom; Andersen, Sigve; Rakaee, Mehrdad; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-25)
      Introduction: <br> To compare the efficacy of silver in situ hybridization (SISH) and immunohistochemistry (IHC) in detecting MET and IGF1R alterations and to investigate their prevalence and prognostic significance. A possible correlation between MET receptor expression, MET gene alterations and the two most frequent occurring EGFR gene mutations was also investigated. <br>Materials and ...

    • Impact of microvessel patterns and immune status in NSCLC: a non-angiogenic vasculature is an independent negative prognostic factor in lung adenocarcinoma 

      Paulsen, Erna-Elise; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona Irene; Lombardi, Ana Paola; Pøhl, Mette; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Pezzella, Francesco; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-26)
      Introduction: Non-small cell lung carcinomas (NSCLC) exhibit different microvessel patterns (MVPs). Basal (BA), diffuse (DA) and papillary (PA) patterns show signs of angiogenesis (new blood vessels), while an alveolar pattern indicates that tumors are co-opting existing normal vessels (non-angiogenic alveolar, NAA). NAA tumor growth is known to exist in NSCLC, but little is known about its prognostic ...

    • Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway 

      Helland, Åslaug; Russnes, Hege Elisabeth Giercksky; Fagereng, Gro Live; Al-Shibli, Khalid Ibrahim; Andersson, Yvonne; Berg, Thomas; Bjørge, Line; Blix, Egil Støre; Bjerkehagen, Bodil; Brabrand, Sigmund; CAMERON, MARTE; Dalhaug, Astrid; Dietzel, Dalia; Dønnem, Tom; Enerly, Espen; Flobak, Åsmund; Fluge, Sverre; Gilje, Bjørnar; Gjertsen, Bjørn Tore; Grønberg, Bjørn Henning; Grønås, Kari; Guren, Tormod Kyrre; Hamre, Hanne Mari; Haug, Åse; Heinrich, Daniel; Hjortland, Geir Olav; Hovig, Eivind; Hovland, Randi; Iversen, Ann-Charlotte; Janssen, Emiel; Kyte, Jon A; Gythfeldt, Hedda; Lothe, Ragnhild Adelheid; Lund, Jo-Åsmund; Meza, Leonardo Zepeda; Munthe-Kaas, Monica Cheng; Nguyen, Olav Toai Duc; Niehusmann, Pitt; Nilsen, Hilde; Puco, Katarina; Ree, Anne Hansen; Riste, Tonje Bøyum; Semb, Karin; Steinskog, Eli Sihn Samdal; Stensvold, Andreas; Suhrke, Pål; Tennøe, Øyvind Krohn; Tjønnfjord, Geir Erland; Vassbotn, Liv Jorunn; Aas, Eline; Aasebø, Kristine Øverås; Tasken, Kjetil; Smeland, Sigbjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-14)
      Background: Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed attention has arisen due to recent advancements in cancer diagnostics including access to high-throughput sequencing of tumour tissue. Targeted therapies interfering with cancer ...

    • Increased levels of microRNA-320 in blood serum and plasma is associated with imminent and advanced lung cancer 

      Nøst, Therese Haugdahl; Skogholt, Anne Heidi; Urbarova, Ilona Halva; Mjelle, Robin; Paulsen, Erna-Elise; Dønnem, Tom; Andersen, Sigve; Markaki, Maria; Røe, Oluf Dimitri; Johansson, Mikael; Johansson, Mattias; Grønberg, Bjørn Henning; Sandanger, Torkjel M; Sætrom, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)
      Lung cancer (LC) incidence is increasing globally and altered levels of microRNAs (miRNAs) in blood may contribute to identification of individuals with LC. We identified miRNAs differentially expressed in peripheral blood at LC diagnosis and evaluated, in pre-diagnostic blood specimens, how long before diagnosis expression changes of such candidate miRNAs could be detected. We identified upregulated ...

    • Independent and Tissue-Specific Prognostic Impact of miR-126 in Nonsmall Cell Lung Cancer 

      Dønnem, Tom; Lønvik, Kenneth; Eklo, Katrine; Berg, Thomas; Sørbye, Sveinung Wergeland; Al-Shibli, Khalid Ibrahim; Al-Saad, Samer; Andersen, Sigve; Stenvold, Helge; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Angiogenesis is pivotal in tumor development. Vascular endothelial growth factor-A (VEGF-A) is considered one of the most important angiogenic factors, but lately several microRNAs (miRs) have been associated with vascular development. miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression ...

    • Low Expression of miR-424-3p is Highly Correlated with Clinical Failure in Prostate Cancer 

      Richardsen, Elin; Andersen, Sigve; Al-Saad, Samer; Rakaee, Mehrdad; Nordby, Yngve; Pedersen, Mona Irene; Ness, Nora; Ingebriktsen, Lise; Fassina, Ambrogio; Tasken, Kristin Austlid; Millls, Ian; Dønnem, Tom; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-23)
      Prostate cancer (PC) is a highly heterogenous disease and one of the leading causes of mortality in developed countries. Recently, studies have shown that expression of immune checkpoint proteins are directly or indirectly repressed by microRNAs (miRs) in many types of cancers. The great advantages of using miRs based therapy is the capacity of these short transcripts to target multiple molecules ...

    • Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial 

      Rakaee, Mehrdad; Andersen, S.; Giannikou, K.; Paulsen, Erna-Elise; Kilvær, Thomas Karsten; Rasmussen Busund, Lill-Tove; Berg, Thomas; Richardsen, Elin; Lombardi, Ana Paola; Adib, E.; Pedersen, Mona Irene; Tafavvoghi, Masoud; Wahl, Sissel Gyrid Freim; Petersen, R.H.; Bondgaard, A.L.; Yde, C.W.; Baudet, C.; Licht, P.; Lund-Iversen, Marius; Grønberg, Bjørn Henning; Fjellbirkeland, Lars; Helland, Åslaug; Pøhl, M.; Kwiatkowski, D.J.; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-24)
      Background - We aim to implement an immune cell score model in routine clinical practice for resected non-small-cell lung cancer (NSCLC) patients (NCT03299478). Molecular and genomic features associated with immune phenotypes in NSCLC have not been explored in detail.<p> <p>Patients and methods - We developed a machine learning (ML)-based model to classify tumors into one of three categories: ...

    • MicroRNA 141 is associated to outcome and aggressive tumor characteristics in prostate cancer 

      Richardsen, Elin; Andersen, Sigve; Melbø-Jørgensen, Christian; Rakaee, Mehrdad; Ness, Nora; Al-Saad, Samer; Nordby, Yngve; Pedersen, Mona Irene; Dønnem, Tom; Bremnes, Roy M.; Rasmussen Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-23)
      A large number of miRNAs influence key cellular processes involved in prostate tumorigenesis. Previous studies have demonstrated high expression of miRNAs in human prostate cancer (PC) tissues and cell lines. In previous microarray data, we found miR-141 to be upregulated and miR-145 to be downregulated in PC. In this large PC cohort (n = 535), we explored the prognostic role of miR-141 and miR-145 ...

    • MicroRNA Signatures in Tumor Tissue Related to Angiogenesis in Non-Small Cell Lung Cancer 

      Dønnem, Tom; Fenton, Christopher Graham; Lønvik, Kenneth; Berg, Thomas; Eklo, Katrine; Andersen, Sigve; Stenvold, Helge; Al-Shibli, Khalid Ibrahim; Al-Saad, Samer; Bremnes, Roy M.; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Angiogenesis is regarded as a hallmark in cancer development, and anti-angiogenic treatment is presently used in non-small cell lung cancer (NSCLC) patients. MicroRNAs (miRs) are small non-coding, endogenous, single stranded RNAs that regulate gene expression. In this study we aimed to identify significantly altered miRs related to angiogenesis in NSCLC. From a large cohort of 335 NSCLC patients, ...

    • Molecular analysis of angiogenic markers as prognostic factors for non-small cell lung cancer (NSCLC) 

      Dønnem, Tom (Doctoral thesis; Doktorgradsavhandling, 2009-03-20)
      Nydannelse av blodkar er avgjørende for at en kreftsvulst skal etablere seg og vokse og et viktig angrepspunkt for ny kreftbehandling. Arbeidet undersøker molekyler som er viktig for reguleringen av blodkardannelse i kreftsvulster og hvordan disse påvirker overlevelsesprognosen for lungekreftpasienter. <br>Avhandlingens tittel er ”Molecular analysis of angiogenic markers as prognostic factors for ...

    • Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival 

      Eilertsen, Marte; Andersen, Sigve; Al-Saad, Samer; Kiselev, Yury; Dønnem, Tom; Stenvold, Helge; Pettersen, Ingvild; Al-Shibli, Khalid; Richardsen, Elin; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Mutasjonstesting ved ikke-småcellet lungekreft 

      Brustugun, Odd Terje; Helland, Åslaug; Fjellbirkeland, Lars; Kleinberg, Lilach; Ariansen, Sarah Louise; Jebsen, Peter Wilhelm; Scott, Helge; Dønnem, Tom; Bremnes, Roy M.; Berg, Thomas; Grønberg, Bjørn Henning; Dai, Hong Yan; Wahl, Sissel Gyrid Freim; Mangseth, Kjersti; Helgeland, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-04-30)
      Bakgrunn. Epidermal vekstfaktorreseptor (EGFR) tyrosinkinasehemmere (EGFR-TKI) er en relativt ny klasse legemidler til behandling av ikke-småcellet lungekreft. Den nasjonale faggruppen for lungekreft, Norsk Lunge Cancer Gruppe, anbefaler at pasienter med ikke-småcellet lungekreft testes for mutasjoner i EGFRgenet. Vi rapporterer her erfaringene som er gjort etter at slik testing ble innført i ...

    • Overexpression of mir-20a-5p in tumor epithelium is an independent negative prognostic indicator in prostate cancer—a multi-institutional study 

      Stoen, Maria J.; Andersen, Sigve; Rakaee, Mehrdad; Pedersen, Mona I.; Ingebriktsen, Lise M.; Dønnem, Tom; Lombardi, Ana P. G.; Kilvaer, Thomas K.; Rasmussen Busund, Lill-Tove; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-14)
      <i>Objective</i>: assessing the prognostic role of miR-20a-5p, in terms of clinical outcome, in a large multi-institutional cohort study.<br><br> <i>Methods</i>: Tissue microarrays from 535 patients’ prostatectomy specimens were constructed. In situ hybridization was performed to assess the expression level of miR-20a-5p in different tissue subregions: tumor stroma (TS) and tumor epithelium (TE). ...

    • Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival 

      Andersen, Sigve; Dønnem, Tom; Stenvold, Helge; Al-Saad, Samer; Al-Shibli, Khalid Ibrahim; Busund, Lill-Tove; Bremnes, Roy M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Hypoxia induced factors (HIFs) are at the heart of the adaptive mechanisms cancer cells must implement for survival. HIFs are regulated by four hydroxylases; Prolyl hydroxylase (PHD)-1,-2,-3 and factor inhibiting HIF (FIH). We aimed to investigate the prognostic impact of these oxygen sensors in NSCLC. Tumor tissue samples from 335 resected stages I to IIIA NSCLC patients was obtained and tissue ...

    • The presence of intraepithelial CD45RO+ cells in resected lymph nodes with metastases from NSCLC patients is an independent predictor of disease-specific survival 

      Kilvær, Thomas Karsten; Paulsen, Erna-Elise; Rakaee, Mehrdad; Al-Saad, Samer; Johansen Maurseth, Ramona; Al-Shibli, Khalid; Bremnes, Roy M.; Busund, Lill-Tove; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-07)
      background: Operable non-small cell lung cancer (NSCLC) patients whose tumours have spread to regional or central lymph nodes at the time of diagnosis have dismal prognoses compared with those who have limited disease. The current TNM staging system for NSCLC poorly distinguishes patients with lymph-node metastases who will succumb to, and those who will eventually be cured from, their disease. ...

    • Profiling of VEGFs and VEGFRs as prognostic factors in soft tissue sarcoma: VEGFR-3 is an independent predictor of poor prognosis 

      Smeland, E; Kilvær, Thomas Karsten; Valkov, Andrey Yurjevich; Sørbye, Sveinung Wergeland; Bremnes, Roy M.; Busund, Lill-Tove Rasmussen; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Progesterone receptors in prostate cancer: Progesterone receptor B is the isoform associated with disease progression 

      Grindstad, Thea K.W.; Richardsen, Elin; Andersen, Sigve; Skjefstad, Kaja Konstanse; Rakaee, Mehrdad; Dønnem, Tom; Ness, Nora; Nordby, Yngve; Bremnes, Roy M.; Al-Saad, Samer; Busund, Lill-Tove (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-27)
      The role of steroid hormones in carcinogenesis of the prostate is to some extent unraveled thorough the effect of androgen deprivation therapy on prostate cancer (PCa) progression. Other members of the steroid hormone family, such as progesterone, are also implicated in PCa, but progesterone’s role remains undefined. This study aimed to examine the distribution of progesterone receptor isoforms ...