Blar i forfatter Det helsevitenskapelige fakultet "Behrends, Christian"

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    • Atg8 family proteins, LIR/AIM motifs and other interaction modes 

      Rogov, Vladimir V.; Nezis, Ioannis P.; Tsapras, P; Zhang, Hong; Dagdas, Yasin; Noda, Nobuo N; Nakatogawa, Hitoshi; Wirth, Martina; Mouilleron, Stephane; McEwan, David G.; Behrends, Christian; Deretic, Vojo P.; Elazar, Zvulun; Tooze, Sharon A.; Dikic, Ivan; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-19)
      The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging. Here, we review the structural and functional features of Atg8 family proteins and their protein-protein interaction modes in model organisms such as yeast, Arabidopsis, ...

    • Membrane Atg8ylation, stress granule formation, and MTOR regulation during lysosomal damage 

      Jia, Jingyue; Wang, Fulong; Bhujabal, Zambarlal Babanrao; Peters, Ryan; Mudd, Michal; Duque, Thabata; Allers, Lee; Javed, Ruheena; Salemi, Michelle; Behrends, Christian; Phinney, Brett; Johansen, Terje; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-29)
      The functions of mammalian Atg8 proteins (mATG8s) expand beyond canonical autophagy and include processes collectively referred to as Atg8ylation. Global modulation of protein synthesis under stress conditions is governed by MTOR and liquid-liquid phase separated condensates containing ribonucleoprotein particles known as stress granules (SGs). We report that lysosomal damage induces SGs acting as ...

    • SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components 

      Abudu, Yakubu Princely; Shrestha, Birendra Kumar; Zhang, Wenxin; Palara, Anthimi; Brenne, Hanne Britt; Larsen, Kenneth Bowitz; Wolfson, Deanna; Dumitriu, Gianina; Øie, Cristina Ionica; Ahluwalia, Balpreet Singh; Levy, Gahl; Behrends, Christian; Tooze, Sharon A; Mouilleron, Stephane; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-26)
      Mitophagy is the degradation of surplus or damaged mitochondria by autophagy. In addition to programmed and stress-induced mitophagy, basal mitophagy processes exert organelle quality control. Here, we show that the sorting and assembly machinery (SAM) complex protein SAMM50 interacts directly with ATG8 family proteins and p62/SQSTM1 to act as a receptor for a basal mitophagy of components of the ...

    • Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage 

      Jia, Jingyue; Wang, Fulong; Bhujabal, Zambarlal Babanrao; Peters, Ryan; Mudd, Michal; Duque, Thabata; Allers, Lee; Javed, Ruheena; Salemi, Michelle; Behrends, Christian; Phinney, Brett; Johansen, Terje; Deretic, Vojo (Journal article; Tidsskriftartikkel; Peer reviewed, 2022)
      We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosomedamaging agents including SARS-CoV-2ORF3a, Mycobacterium tuberculosis, and proteopathic tau. During damage, mammalian ATG8s directly interacted with the ...