Browsing Det helsevitenskapelige fakultet by Author "Borøy, Vegard"

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    • Development of DNA Nanoparticles with Properties for Enhanced Biofilm Uptake 

      Borøy, Vegard (Mastergradsoppgave; Master thesis, 2022-05-11)
      Microbial biofilms account for up to 80% of all bacterial infections. They are described as small structural communities of bacteria which are embedded in a self-produced extracellular (EPS) matrix. This EPS matrix poses a substantial challenge for antimicrobial treatment by hindering traversal of antimicrobial agents. Nanotechnology based drug delivery systems (DDS) offer a promising solution ...

    • Polymyxin B stabilized DNA micelles for sustained antibacterial and antibiofilm activity against P. aeruginosa 

      Antunes de Sousa, Alexandra Sofia; Borøy, Vegard; Bæverud, Agnethe Hansen; Julin, Kjersti; Bayer, Annette; Strøm, Morten B.; Johannessen, Mona Susan; Skalko Basnet, Natasa; Obuobi, Sybil Akua Okyerewa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-21)
      Nucleic acid-based materials showcase an increasing potential for antimicrobial drug delivery. Although numerous reports on drug-loaded DNA nanoparticles outline their pivotal antibacterial activities, their potential as drug delivery systems against bacterial biofilms awaits further studies. Among different oligonucleotide structures, micellar nanocarriers derived from amphiphilic DNA strands ...