van Os, Elise Anne; Cools, Laura; Eysackers, Nathalie; Szafranska, Karolina; Smout, Ayla; Verhulst, Stefaan; Reynaert, Hendrik; McCourt, Peter Anthony; Mannaerts, Inge; van Grunsven, Leo A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-28)
Chronic liver disease can lead to liver fibrosis and ultimately cirrhosis, which is a significant health burden and a
major cause of death worldwide. Reliable in vitro models are lacking and thus mono-cultures of cell lines are still
used to study liver disease and evaluate candidate anti-fibrotic drugs. We established functional multicellular
liver spheroid (MCLS) cultures using primary mouse ...