Blar i forfatter Det helsevitenskapelige fakultet "Dou, Zhixun"

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    • SIRT1 - a new mammalian substrate of nuclear autophagy 

      Wang, Lu; Xu, Caiyue; Johansen, Terje; Berger, Shelley L.; Dou, Zhixun (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-20)
      Macroautophagic/autophagic degradation of nuclear components (or nuclear autophagy) is a poorly understood area in autophagy research. We previously reported the nuclear lamina protein LMNB1 (lamin B1) as a nuclear autophagy substrate in primary human cells, stimulating the investigation of nuclear autophagy in the mammalian system. We recently reported the sirtuin protein SIRT1 as a new selective ...

    • SIRT1 is downregulated by autophagy in senescence and ageing 

      Xu, Caiyue; Wang, Lu; Fozouni, Parinaz; Evjen, Gry; Chandra, Vemika; Jiang, Jing; Lu, Congcong; Nicastri, Michael; Bretz, Corey; Winkler, Jeffrey D.; Amaravadi, Ravi; Garcia, Benjamin A.; Adams, Peter D.; Ott, Melanie; Tong, Wei; Johansen, Terje; Dou, Zhixun; Berger, Shelley L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-28)
      SIRT1 (Sir2) is an NAD<sup>+</sup>-dependent deacetylase that plays critical roles in a broad range of biological events, including metabolism, the immune response and ageing<sup>1,2,3,4,5</sup>. Although there is strong interest in stimulating SIRT1 catalytic activity, the homeostasis of SIRT1 at the protein level is poorly understood. Here we report that macroautophagy (hereafter referred to as ...