Chalabianloo, Fatemeh; Høiseth, Gudrun; Vold, Jørn Henrik; Johansson, Kjell Arne; Kringen, Marianne K.; Dalgard, Olav; Ohldieck, Christian; Druckrey-Fiskaaen, Karl Trygve; Aas, Christer Frode; Løberg, Else-Marie; Bramness, Jørgen Gustav; Fadnes, Lars T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
Background: There is limited knowledge on the causes of large variations in serum
methadone concentrations and dose requirements.
Objectives: We investigated the impact of the degree of liver fibrosis on dose-adjusted
steady-state serum methadone concentrations.<p>
<p<Methods: We assessed the clinical and laboratory data of 155 Norwegian patients with
opioid use disorder undergoing methadone ...