Blar i forfatter Det helsevitenskapelige fakultet "Englert, Hanna"

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    • Intrinsic coagulation pathway-mediated thrombin generation in mouse whole blood 

      Konrath, Sandra; Mailer, Reiner K.; Beerens, Manu; Englert, Hanna; Frye, Maike; Kuta, Piotr; Preston, Roger J. S.; Maas, Coen; Butler, Lynn; Roest, Mark; de Laat, Bas; Renné, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-28)
      Calibrated Automated Thrombography (CAT) is a versatile and sensitive method for analyzing coagulation reactions culminating in thrombin generation (TG). Here, we present a CAT method for analyzing TG in murine whole blood by adapting the CAT assay used for measuring TG in human plasma. The diagnostically used artificial and physiologic factor XII (FXII) contact activators kaolin, ellagic acid ...

    • Targeting NETs using dual-active DNase1 variants 

      Englert, Hanna; Göbel, Josephine; Khong, Danika; Omidi, Maryam; Wolska, Nina; Konrath, Sandra; Frye, Maike; Mailer, Reiner K.; Beerens, Manu; Gerwers, Julian C.; Preston, Roger J. S.; Odeberg, Jacob; Butler, Lynn; Maas, Coen; Stavrou, Evi X.; Fuchs, Tobias A.; Renné, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-23)
      Background: Neutrophil Extracellular Traps (NETs) are key mediators of immunothrombotic mechanisms and defective clearance of NETs from the circulation underlies an array of thrombotic, inflammatory, infectious, and autoimmune diseases. Efficient NET degradation depends on the combined activity of two distinct DNases, DNase1 and DNase1-like 3 (DNase1L3) that preferentially digest double-stranded DNA ...