Blar i forfatter Det helsevitenskapelige fakultet "Enyedy, Istvan"

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    • Identification and experimental confirmation of novel cGMP efflux inhibitors by virtual ligand screening of vardenafil-analogues 

      Kashgari, Farzane Kuresh; Ravna, Aina Westrheim; Sager, Georg; Lyså, Roy Andre; Enyedy, Istvan; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-28)
      <i>Background</i> - Clinical studies have reported overexpression of PDE5 and elevation of intracellular cyclic GMP in various types of cancer cells. ABCC5 transports cGMP out of the cells with high affinity. PDE5 inhibitors prevent both cellular metabolism and cGMP efflux by inhibiting ABCC5 as well as PDE5. Increasing intracellular cGMP is hypothesized to promote apoptosis and growth restriction ...