Blar i forfatter Det helsevitenskapelige fakultet "Fadnes, Lars T."

Viser treff 1-2 av 2

    • Impact of liver fibrosis and clinical characteristics on dose-adjusted serum methadone concentrations 

      Chalabianloo, Fatemeh; Høiseth, Gudrun; Vold, Jørn Henrik; Johansson, Kjell Arne; Kringen, Marianne K.; Dalgard, Olav; Ohldieck, Christian; Druckrey-Fiskaaen, Karl Trygve; Aas, Christer Frode; Løberg, Else-Marie; Bramness, Jørgen Gustav; Fadnes, Lars T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
      Background: There is limited knowledge on the causes of large variations in serum methadone concentrations and dose requirements. Objectives: We investigated the impact of the degree of liver fibrosis on dose-adjusted steady-state serum methadone concentrations.<p> <p<Methods: We assessed the clinical and laboratory data of 155 Norwegian patients with opioid use disorder undergoing methadone ...

    • Subjective symptoms and serum methadone concentrations: what should guide dose adjustments in methadone maintenance treatment? A naturalistic cohort study from Norway 

      Chalabianloo, Fatemeh; Fadnes, Lars T.; Høiseth, Gudrun; Ohldieck, Christian; Vold, Jørn Henrik; Aas, Christer Frode; Løberg, Else-Marie; Johansson, Kjell Arne; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-03)
      <i>Background</i> - There is little evidence-based guidance on how to optimize methadone dosages among patients with opioid addiction undergoing methadone maintenance treatment (MMT). This study aims to investigate whether self-perceived opioid withdrawal symptoms, adverse effects, and self-reported substance use in patients on MMT are related to serum methadone concentrations and the role that these ...