Blar i forfatter Det helsevitenskapelige fakultet "Giordani, Barbara"

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    • Lecithin and Chitosan as Building Blocks in Anti-Candida Clotrimazole Nanoparticles 

      Hemmingsen, Lisa Myrseth; Panzacchi, Virginia; Kangu, Lloyd Mbugua; Giordani, Barbara; Luppi, Barbara; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-25)
      The main focus when considering treatment of non-healing and infected wounds is tied to the microbial, particularly bacterial, burden within the wound bed. However, as fungal contributions in these microbial communities become more recognized, the focus needs to be broadened, and the remaining participants in the complex wound microbiome need to be addressed in the development of new treatment ...

    • Liposomes-in-chitosan hydrogel boosts potential of chlorhexidine in biofilm eradication in vitro 

      Hemmingsen, Lisa Myrseth; Giordani, Barbara; Pettersen, Ann Kristin; Vitali, Beatrice; Basnet, Purusotam; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-16)
      Successful treatment of skin infections requires eradication of biofilms found in up to 90 % of all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity of liposomally-associated membrane active antimicrobials (MAA) and could potentially improve bacterial and biofilm eradication. Therefore, liposomes (∼300 nm) bearing chlorhexidine ...

    • Tailored anti-biofilm activity – Liposomal delivery for mimic of small antimicrobial peptide 

      Hemmingsen, Lisa Myrseth; Giordani, Barbara; Paulsen, Marianne Hagensen; Vanic, Zeljka; Flaten, Gøril Eide; Vitali, Beatrice; Basnet, Purusotam; Bayer, Annette; Strøm, Morten B.; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-13)
      The eradication of bacteria embedded in biofilms is among the most challenging obstacles in the management of chronic wounds. These biofilms are found in most chronic wounds; moreover, the biofilm-embedded bacteria are considerably less susceptible to conventional antimicrobial treatment than the planktonic bacteria. Antimicrobial peptides and their mimics are considered attractive candidates in the ...

    • Utilizing Liposomal Quercetin and Gallic Acid in Localized Treatment of Vaginal Candida Infections 

      Giordani, Barbara; Basnet, Purusotam; Mishchenko, Ekaterina; Luppi, Barbara; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-20)
      Vulvovaginal candidiasis (VVC) is a widely spread fungal infection that causes itching, pain and inflammation at the vaginal site. Although common, currently available treatment suffers from limited efficacy and high recurrence. In addition, the growing problem of resistance to azole drugs used in current treatments emphasizes the need for superior treatment options. Antimicrobial polyphenols are ...