Blar i forfatter Det helsevitenskapelige fakultet "Håheim, Brage"
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Accidental hypothermia - A review on the underlying physiological and pathophysiological mechanisms and treatment of accidental hypothermia
Håheim, Brage (Master thesis; Mastergradsoppgave, 2014-06-01)Accidental hypothermia is a rare condition with few deaths per year, but hypothermic patients have a 30% chance of dying. The past 15-20 years there has been an increased understanding of how hypothermia affects human physiology and may cause life-threatening conditions like arrhythmias, cardiovascular shock and pulmonary edema. New understanding of underlying mechanisms of hypothermia- induced ... -
Comparison between two pharmacologic strategies to alleviate rewarming shock: vasodilation vs. inodilation
Håheim, Brage; Kondratyev, Timofey; Dietrichs, Erik Sveberg; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-12)Rewarming from hypothermia is often challenged by coexisting cardiac dysfunction, depressed organ blood flow (OBF), and increased systemic vascular resistance. Previous research shows cardiovascular inotropic support and vasodilation during rewarming to elevate cardiac output (CO). The present study aims to compare the effects of inodilatation by levosimendan (LS) and vasodilation by nitroprusside ... -
The hemodynamic aspects of pharmacological manipulation of cardiac contractility and vascular resistance in rewarming from hypothermia
Håheim, Brage (Doctoral thesis; Doktorgradsavhandling, 2018-12-07)<p><i>Paper I</i> <br>To describe hemodynamic response and phosphorylation of cardiac troponin I during rewarming from deep, stable hypothermia with use of the calcium sensitizer and PDE3 inhibitor levosimendan, compared to animals given placebo. <p> <p><i>Paper II</i> <br>To describe hemodynamic response to lowered systemic vascular resistance by nitroprusside administration during rewarming ...