Blar i forfatter Det helsevitenskapelige fakultet "Hopper, John L."

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    • Are the Relationships of Lean Mass and Fat Mass With Bone Microarchitecture Causal or Due to Familial Confounders? A Novel Study of Adult Female Twin Pairs 

      Bui, Minh; Zebaze, Roger; Li, Shuai; Hopper, John L.; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-01)
      It is not known whether the relationships of lean mass (LM) and fat mass (FM) with bone microarchitecture and geometry are causal and/or are because of confounders, including familial confounders arising from genetic and environment effects shared by relatives. We tested the hypotheses that: (i) LM is associated with cortical bone traits, (ii) FM is associated with trabecular bone traits, and (iii) ...

    • Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival 

      Morra, Anna; Schreurs, Maartje A. C.; Andrulis, Irene L.; Anton-Culver, Hoda; Augustinsson, Annelie; Beckmann, Matthias W.; Behrens, Sabine; Bojesen, Stig E.; Bolla, Manjeet K.; Brauch, Hiltrud; Broeks, Annegien; Buys, Saundra S.; Camp, Nicola J.; Castelao, Jose E.; Cessna, Melissa H.; Chang-Claude, Jenny; Chung, Wendy K.; Sahlberg, Guro Kristine Kleivi; Børresen-Dale, Anne-Lise; Gram, Inger Torhild; Olsen, Karina Standahl; Engebråten, Olav; Naume, Bjørn; Geisler, Jürgen; Grenaker, Grethe Irene; Colonna, Sarah V.; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Czene, Kamila; Daly, Mary B.; Dennis, Joe; Devilee, Peter; Dörk, Thilo; Dunning, Alison M.; Dwek, Miriam; Easton, Douglas F.; Eccles, Diana M.; Eriksson, Mikael; Evans, D. Gareth; Fasching, Peter A.; Fehm, Tanja N.; Figueroa, Jonine D.; Flyger, Henrik; Gabrielson, Marike; Gago-Dominguez, Manuela; García-Closas, Montserrat; García-Sáenz, José A.; Genkinger, Jeanine; Grassmann, Felix; Gündert, Melanie; Hahnen, Eric; Haiman, Christopher A.; Hamann, Ute; Harrington, Patricia A.; Hartikainen, Jaana M.; Hoppe, Reiner; Hopper, John L.; Houlston, Richard S.; Howell, Anthony; Jakubowska, Anna; Janni, Wolfgang; Jernström, Helena; John, Esther M.; Johnson, Nichola; Jones, Michael E.; Kristensen, Vessela N.; Kurian, Allison W.; Lambrechts, Diether; Le Marchand, Loic; Lindblom, Annika; Lubiński, Jan; Lux, Michael P.; Mannermaa, Arto; Mavroudis, Dimitrios; Mulligan, Anna Marie; Muranen, Taru A.; Nevanlinna, Heli; Nevelsteen, Ines; Neven, Patrick; Newman, William G.; Obi, Nadia; Offit, Kenneth; Olshan, Andrew F.; Park-Simon, Tjoung-Won; Patel, Alpa V.; Peterlongo, Paolo; Phillips, Kelly-Anne; Plaseska-Karanfilska, Dijana; Polley, Eric C.; Presneau, Nadege; Pylkäs, Katri; Rack, Brigitte; Radice, Paolo; Rashid, Muhammad U.; Rhenius, Valerie; Robson, Mark; Romero, Atocha; Saloustros, Emmanouil; Sawyer, Elinor J.; Schmutzler, Rita K.; Schuetze, Sabine; Scott, Christopher; Shah, Mitul; Smichkoska, Snezhana; Southey, Melissa C.; Tapper, William J.; Teras, Lauren R.; Tollenaar, Rob A. E. M.; Tomczyk, Katarzyna; Tomlinson, Ian; Troester, Melissa A.; Vachon, Celine M.; van Veen, Elke M.; Wang, Qin; Wendt, Camilla; Wildiers, Hans; Winqvist, Robert; Ziogas, Argyrios; Hall, Per; Pharoah, Paul D. P.; Adank, Muriel A.; Hollestelle, Antoinette; Schmidt, Marjanka K.; Hooning, Maartje J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-03)
      Background - Breast cancer (BC) patients with a germline CHEK2 c.1100delC variant have an increased risk of contralateral BC (CBC) and worse BC-specific survival (BCSS) compared to non-carriers.<p> <p>Aim - To assessed the associations of CHEK2 c.1100delC, radiotherapy, and systemic treatment with CBC risk and BCSS.<p> <p>Methods - Analyses were based on 82,701 women diagnosed with a first ...

    • Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies 

      Jayasekara, Harindra; MacInnis, Robert J.; Lujan-Barroso, Leila; Mayen-Chacon, Ana-Lucia; Cross, Amanda J.; Wallner, Bengt; Palli, Domenico; Ricceri, Fulvio; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Kühn, Tilman; Kaaks, Rudolf; Tsilidis, Konstantinos K.; Sánchez, Maria-Jose; Amiano, Pilar; Ardanaz, Eva; Chirlaque López, María Dolores; Merino, Susana; Boutron-Ruault, Marie-Christine; Severi, Gianluca; Sternby, Hanna; Sonestedt, Emily; Bueno-de-Mesquita, Bas; Boeing, Heiner; Travis, Ruth C.; Sandanger, Torkjel M; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Tjønneland, Anne; Yang, Yi; Hodge, Allison M.; Mitchell, Hazel; Haydon, Andrew; Room, R; Hopper, John L.; Weiderpass, Elisabete; Gunter, Marc J.; Riboli, Elio; Giles, Graham G.; Milne, Roger L.; Agudo, Antonio; English, Dallas R.; Ferrari, Pietro (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-07)
      Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne ...

    • Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms 

      Gagliardi, Amedeo; Dugué, Pierre-Antoine; Nøst, Therese Haugdahl; Southey, Melissa C.; Buchanan, Daniel D.; Schmidt, Daniel F; Makalic, Enes; Hodge, Allison M; English, Dallas R.; Wong Doo, Nicole; Hopper, John L.; Severi, Gianluca; Baglietto, Laura; Naccarati, Alessio; Krogh, Vittorio; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Tumino, Rosario; Lund, Eiliv; Giles, Graham; Pardini, Barbara; Sandanger, Torkjel M; Milne, Roger L.; Paolo, Vineis; Polidoro, Silvia; Fiorito, Giovanni (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-11)
      <p>Background: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic epigenetic mutations (SEM) has been suggested as a biomarker of life-course accumulation of exposure-related DNA damage; however, the predictive role of SEMs in cancer has seldom been investigated. <p>Methods: A SEM, at a given CpG site, was defined as an extreme ...