• Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study 

      Beqiri, Erta; Smielewski, Peter; Guérin, Claude; Czosnyka, Marek; Robba, Chiara; Bjertnæs, Lars Jakob; K Frisvold, Shirin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-20)
      Introduction - Lung protective ventilation (LPV) comprising low tidal volume (VT) and high positive end-expiratory pressure (PEEP) may compromise cerebral perfusion in acute brain injury (ABI). In patients with ABI, we investigated whether LPV is associated with increased intracranial pressure (ICP) and/or deranged cerebral autoregulation (CA), brain compensatory reserve and oxygenation.<p> <p>Methods ...
    • Respiratory challenges and ventilatory management in different types of acute brain-injured patients 

      K Frisvold, Shirin; Coppola, S.; Ehrmann, S.; Chiumello, D.; Guérin, Claude (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-23)
      Acute brain injury (ABI) covers various clinical entities that may require invasive mechanical ventilation (MV) in the intensive care unit (ICU). The goal of MV, which is to protect the lung and the brain from further injury, may be difficult to achieve in the most severe forms of lung or brain injury. This narrative review aims to address the respiratory issues and ventilator management, specific ...