Blar i forfatter Det helsevitenskapelige fakultet "Ladd, Patricia"

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    • Molecular programs associated with glomerular hyperfiltration in early diabetic kidney disease 

      Stefansson, Vidar Tor Nyborg; Nair, Viji; Melsom, Toralf; Looker, Helen C.; Mariani, Laura H.; Fermin, Damian; Eichinger, Felix; Menon, Rajasree; Subramanian, Lalita; Ladd, Patricia; Harned, Roger; Harder, Jennifer L.; Hodgin, Jeffrey B.; Bjornstad, Petter; Nelson, Peter J.; Eriksen, Bjørn Odvar; Nelson, Robert G.; Kretzler, Matthias (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-31)
      Hyperfiltration is a state of high glomerular filtration rate (GFR) observed in early diabetes that damages glomeruli, resulting in an iterative process of increasing filtration load on fewer and fewer remaining functional glomeruli. To delineate underlying cellular mechanisms of damage associated with hyperfiltration, transcriptional profiles of kidney biopsies from Pima Indians with type 2 ...