Blar i forfatter Det helsevitenskapelige fakultet "Leitch, Calum"

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    • Inhibition of a new AXL isoform (AXL3) induces apoptosis of mantle cell lymphoma cells 

      Gelebart, Pascal Francois; Gjerstad, May Eriksen; Benjaminsen, Susanne; Han, Jianhua; Karlsen, Ida; Mayoral Safont, Mireia; Leitch, Calum; Fandalyuk, Zinayida; Popa, Mihaela-Lucia; Helgeland, Lars; Papp, Bela; Baran-Marszak, Fanny; Mc Cormack, Emmet (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-20)
      Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma having a poor overall survival that is in need for the development of new therapeutics. In this study, we report the identification and expression of a new isoform splice variant of the tyrosine kinase receptor AXL in MCL cells. This new AXL isoform, called AXL3, lacks the ligand-binding domain of the commonly described AXL ...