Blar i forfatter Det helsevitenskapelige fakultet "Fredriksen, Line Mari"
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A study on the autophagy receptor p62/SQSTM1. Impact of ATF4 and 5´untranslated region of mRNA upon amino acid deprivation
Fredriksen, Line Mari (Master thesis; Mastergradsoppgave, 2015-05-13)Autophagy is crucial for sustainment of cellular homeostasis, but there is limited knowledge of how autophagy is regulated. The present study examined characteristics of the first mammalian autophagy receptor described, the sequestosome-1 or p62/ SQSTM1, regarding transcriptional and translational expression under stress by amino acid starvation in the mammalian Hek293 cells. Reviews report p62 ...