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    • DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription 

      Sancho, Ana; Duran, Jordi; Garcia-Espana, Antonio; Mauvezin, Caroline; Alemu, Endalkachew Ashenafi; Lamark, Trond; Macias, Maria J.; DeSalle, Rob; Royo, Miriam; Sala, David; Chicote, Javier U.; Palacin, Manuel; Johansen, Terje; Zorzano, Antonio (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Human DOR/TP53INP2 displays a unique bifunctional role as a modulator of autophagy and gene transcription. However, the domains or regions of DOR that participate in those functions have not been identified. Here we have performed structure/function analyses of DOR guided by identification of conserved regions in the DOR gene family by phylogenetic reconstructions. We show that DOR is present in ...