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    • Structural and biochemical investigation of Metallo-β-lactamases : insights into antibiotic binding sites 

      Naga Pardha Saradhi, Borra (Doctoral thesis; Doktorgradsavhandling, 2012-09-25)
      The emergence of multidrug-resistant (MDR) Gram-negative pathogens and lack of new antibiotics in the pharmaceutical pipeline is seriously limiting our treatment options against common infections. We are now experiencing clinical isolates resistant to virtually all our antibiotics. Our most important and widely used antibiotics, the β-lactams, are challenged by successful β-lactamases. β-lactamases ...