Now showing items 1-1 of 1

    • Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability 

      Sanna, S; Li, BS; Mulas, A; Sidore, C; Kang, HM; Jackson, AU; Piras, MG; Usala, G; Maninchedda, G; Sassu, A; Serra, F; Palmas, MA; Wood, WH; Njølstad, Inger; Laakso, M; Hveem, Kristian; Tuomilehto, J; Lakka, TA; Rauramaa, R; Boehnke, M; Cucca, F; Uda, M; Schlessinger, D; Nagaraja, R; Abecasis, GR (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Complex trait genome-wide association studies (GWAS) provide an efficient strategy for evaluating large numbers of common variants in large numbers of individuals and for identifying trait-associated variants. Nevertheless, GWAS often leave much of the trait heritability unexplained. We hypothesized that some of this unexplained heritability might be due to common and rare variants that reside in ...