Det helsevitenskapelige fakultet: Nye registreringer
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Mediating Role of Lifestyle Behaviors in the Association between Education and Cancer: Results from the European Prospective Investigation into Cancer and Nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-09)Background: Many studies have shown that socioeconomic position (SEP) is associated with the incidence of malignant tumors at different sites. This study aims to estimate the association between educational level (as proxy for SEP) and cancer incidence and to understand whether the observed associations might be partially explained by lifestyle behaviors.<p> <p>Methods: The analyses were performed ... -
Multiple Chemical Sensitivity: Catching up to what kind of science?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-27)The recent review of Molot et al. (2023) appropriately emphasizes Multiple Chemical Sensitivity (MCS) as a growing health issue and the necessity of dedicated healthcare and medical education. The authors explain MCS mainly as the result of the sensitization of transient receptor potential (TRP) receptors, notably TRPV1 and TRPA1, and oppose this explanation to psychological processes as a causal ... -
AI Risk Score on Screening Mammograms Preceding Breast Cancer Diagnosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-17)More than 38% of both screen-detected and interval cancers were assigned the highest artificial intelligence risk score on screening mammograms that preceded breast cancer diagnosis.<p> <p>Background - Few studies have evaluated the role of artificial intelligence (AI) in prior screening mammography.<p> <p>Purpose - To examine AI risk scores assigned to screening mammography in women who were ... -
Electrohypersensitivity is always real
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-01)Given the rapid increase of electromagnetic fields in our environment, the recent review paper by Belpomme and Irigaray (2022) (https://doi.org/10.1016/j.envres.2022.113374) is timely in trying to integrate and discuss the available evidence to understand electrohypersensitivity (EHS), also called idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) or symptoms associated ... -
The bacterial magnesium transporter MgtA reveals highly selective interaction with specific cardiolipin species
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-23)The bacterial magnesium transporter A (MgtA) is a specialized P-type ATPase important for Mg<sup>2+</sup> import into the cytoplasm; disrupted magnesium homeostasis is linked to intrinsic ribosome instability and antibacterial resistance in Salmonella strains. Here, we show that MgtA has functional specificity for cardiolipin 18:1. Still, it reaches maximum activity only in combination with ... -
Investigating the effects of the ketone body ß-hydroxybutyrate and the anti-cancer compound MHP88 on glioblastoma multiforme cells in vitro
(Mastergradsoppgave; Master thesis, 2021-05-16)Introduction: Glioblastoma multiforme (GBM) is the most aggressive human brain tumor with a mean survival of 15 months. It is therefore necessary to explore new treatment strategies, and to study how different hallmarks of cancer can be utilized in this regard. The marine natural product mimic MHP88 can attack the cancer cells’ ability to evade immune destruction by inducing immunogenic cell death ... -
Seksuelle overgrep begått av voksne eller jevnaldrende: risikofaktorer, psykisk helse og livskvalitet i et representativt ungdomsutvalg
(Mastergradsoppgave; Master thesis, 2022-02-15)Bakgrunn: Rundt halvparten av seksuelle overgrep mot barn og unge begås av jevnaldrende, likevel vet vi lite om forskjeller i risikofaktorer og helsekonsekvenser relatert til om overgriperen har vært voksen eller jevnaldrende. Formål: Studien undersøker risikofaktorer, psykisk helse og livskvalitet relatert til seksuelle overgrep, og forskjeller relatert til om overgrepet ble begått av voksne eller ... -
“I See What You Feel”: An Exploratory Study to Investigate the Understanding of Robot Emotions in Deaf Children
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-09)Research in the field of human–robot interactions (HRIs) has advanced significantly in recent years. Social humanoid robots have undergone severe testing and have been implemented in a variety of settings, for example, in educational institutions, healthcare facilities, and senior care centers. Humanoid robots have also been assessed across different population groups. However, research on various ... -
Homologous Recombination Deficiency Across Subtypes of Primary Breast Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-01)Purpose - Homologous recombination deficiency (HRD) is highly prevalent in triple-negative breast cancer (TNBC) and associated with response to PARP inhibition (PARPi). Here, we studied the prevalence of HRD in non-TNBC to assess the potential for PARPi in a wider group of patients with breast cancer.<p> <p>Methods - HRD status was established using targeted gene panel sequencing (360 genes) and ... -
Evaluation of Sexual Behavior in Laboratory vs Seminatural Conditions
(Chapter; Bokkapittel, 2023-05-17)Sexual behavior is, by necessity, sexually dimorphic. Males transfer sperm to females, whereas females receive sperm from males. Discussions of sex differences in copulatory behavior are consequently trivial. However, the behaviors associated with copulation, for example mate choice or postcopulatory reactions, may well be similar in males and females. Such differences, even subtle, are far easier ... -
Personsentrert sykepleiefaglig ledelse og arbeidskultur
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-29)The aim of this qualitative research project is to explore how person-centred nursing leadership can promote work culture in nursing homes. The focus is on leaders and caregivers at a department level in the nursing home. Interviews were analysed by content analysis and theoretical perspectives from person-centred nursing leadership. Professional cooperation, present and perceptive leaders, as well ... -
Climate Change Causes Molecular-Level Stress Responses
(Journal article; Tidsskriftartikkel, 2019)Anemones are abundant in an acidified ocean. But are they thriving? New genomics research shows that ocean acidification puts these animals under considerable stress. The good news is that some marine animals can tolerate the impacts of increased carbon dioxide levels in seawater. -
Er legerollen uforenlig med dødshjelp?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023)En problemstilling idødshjelpsdeba en er hvordan dødshjelp kan forenes etisk med rollen som helsepersonell, og spesielt med rollen som behandlende lege. Andelen leger som stø er legalisering av dødshjelp er økende, og en prosess for åavklare legens mulige oppgaver ved livets slu er derfor betimelig. Legeyrket innebærer ere faglige roller, en av dem er åvære sakkyndig. Vi skisserer en hypotetisk ... -
Lifestyle interventions to change trajectories of obesity-related cardiovascular risk from childhood onset to manifestation in adulthood: a joint scientific statement of the task force for childhood health of the European Association of Preventive Cardiology and the European Childhood Obesity Group
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-25)There is an immediate need to optimize cardiovascular (CV) risk management and primary prevention of childhood obesity to timely and more effectively combat the health hazard and socioeconomic burden of CV disease from childhood development to adulthood manifestation. Optimizing screening programs and risk management strategies for obesity-related CV risk in childhood has high potential to change ... -
National health registries – a ‘goldmine’ for studying non-communicable disease occurrence in Norway – the NCDNOR project
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-10)To estimate occurrence of non-communicable diseases (NCDs) over the life-course in the Norwegian population, national health registries are a vital source of information since they fully represent the entire non-institutionalised population. However, as they are mainly established for administrative purposes, more knowledge about how NCDs are recorded in the registries is needed. To establish this, ... -
Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-16)Aims - The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age and does not include estimated glomerular filtration rate (eGFR) and albuminuria in its algorithms, systemic coronary risk estimation 2 (SCORE2) and systemic ... -
Recommendations for the development, implementation, and reporting of control interventions in efficacy and mechanistic trials of physical, psychological, and self-management therapies: the CoPPS Statement
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-25)Control interventions (often called “sham,” “placebo,” or “attention controls”) are essential for studying the efficacy or mechanism of physical, psychological, and self-management interventions in clinical trials. This article presents core recommendations for designing, conducting, and reporting control interventions to establish a quality standard in non-pharmacological intervention research. A ... -
Variation in antibiotic consumption in very preterm infants-a 10 year population-based study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-21)Objectives: Wide variations in antibiotic use in very preterm infants have been reported across centres despite similar rates of infection. We describe 10 year trends in use of antibiotics and regional variations among very preterm infants in Norway. Patients and Methods: All live-born very preterm infants (<32 weeks gestation) admitted to any neonatal unit in Norway during 2009–18 were included. ... -
What is a High-Quality Moral Case Deliberation?-Facilitators’ Perspectives in the Euro-MCD Project
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-05)The evaluation of the European Moral Case Deliberation Outcomes project (EuroMCD) has resulted in a revised evaluation instrument, knowledge about the content of MCD (moral case deliberation), and the perspectives of those involved. In this paper, we report on a perspective that has been overlooked, the facilitators’. We aim to describe facilitators’ perceptions of high-quality moral case ... -
Outcome of aneurysmal subarachnoid hemorrhage in a population-based cohort: Retrospective registry study
(Master thesis; Mastergradsoppgave, 2023-10-31)Background: Studies of aneurysmal subarachnoid hemorrhage (aSAH) report an association between higher patient volumes and better outcomes. In regions with dispersed settlement, this must be balanced against the advantages with shorter pre-hospital transport times and timely access. The aim of this study is to report outcome for unselected aSAH-cases from a well-defined rural population treated in a ...