Blar i forfatter Artikler, rapporter og annet (fysikk og teknologi) "Cagnetta, Roberta"

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    • On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons 

      Shigeoka, Toshiaki; Koppers, Max; Wong, Hovy Ho Wai; Lin, Julie Qiaojin; Cagnetta, Roberta; Dwivedy, Asha; de Freitas Nascimento, Janaina; van Tartwijk, Francesca W.; Ströhl, Florian; Cioni, Jean Michel; Schaeffer, Julia; Carrington, Mark; Kaminski, Clemens F.; Jung, Hosung; Harris, William A.; Holt, Christine E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-10)
      Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies. Here, we report a physical and functional interaction between locally synthesized RPs and ribosomes in the axon. We show that axonal RP translation is regulated through a sequence motif, ...